why are g protein important for drug discovery?

Answers

Answer 1

Answer:

G protein - coupled  receptors(GPCRs)n belong to a large family of signaling proteins that  mediate cellular  reponses to most hormones ,metabolites,cytokines and neuotransmitters and therefore serve as fritful targets for DRUGS DISCOVERYS.

Explanation: histamine(HRH1),serotonin dopamine,opiod and adrenergic receptors.

I HOPE IT'S HELPS YOU TO UNDERSTAND


Related Questions

A paleontologist finds a relatively complete skeleton but isn’t sure if it is an ape fossil or a hominid fossil. Which of the following features would NOT help distinguish between the two choices?
a. position of the opening in the skull for the spinal cord
b. design of the pelvis
c. relative length of the hind limbs
d. position of the eyes

Answers

c. relative length of the hind limbs. Overall fossilized apes and hominids are 90+% similar in the past 3.5 million years since Australopithecus afarensis but this one aspect of upper vs. lower limbs is the greatest difference. Hope this helps!

Which sentence about protist is accurate

Answers

Answer:

there are no sentences

Explanation:

What is the only source of energy production for RBCs?

Answers

Answer:

Anaerobic oxidation of glucose

What makes up the backbone of a DNA molecule? nucleic acids RNA molecules sugars and phosphates ribose and deoxyribose

Answers

Base, sugar and phosphate and deoxyribose make up a nucleotide on a DNA molecule

Answer:

sugars and phosphates

Explanation:

gradpoint

The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane

Answers

Answer:

The question is incomplete, below is the completed question:

The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane ?

a. Diffusion, or passive transport, occurs when molecules diffuse from a lower concentration to a higher concentration.

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

c. The lipid bilayer opens up and allows the ions or molecules to enter the cell, then closes.

d. Active transport occurs when molecules diffuse from a higher concentration to a lower concentration.

Answer:

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

Explanation:

Transport through cell membranes can be broadly classified as active transport or passive transport.

Active transport requires energy in the form of ATP for the transportation of substances across the cell membrane.

Option b correctly describes facilitated diffusion, which is a passive-mediated diffusion process, where channels in the cell membrane mainly composed of proteins called transmembrane integral proteins, allow for the movement of certain molecules (mostly polar/hydrophilic) molecules that will not otherwise be transported through simple diffusion because of the hydrophobic nature of the cell membrane.

The other options are wrong because:

a. diffusion or simple transport involves the movement of substances from regions of higher to a lower concentration not lower to higher as suggested here.

c. The lipid bi-layer does not allow ions or hydrophilic molecules because it is hydrophobic in nature, and it is not a channel, so it does not open and closes

d. In active transport, transfer of molecules is from regions of lower to higher concentration and not higher to lower concentration as suggested here.

____________ a regulatory protein that may bind DNA to inhibit transcription. ____________ a DNA sequence that binds a regulatory protein. ____________a DNA sequence that binds RNA polymerase and regulates transcription. ____________a compound that interacts with another protein or compound to form an active repressor ____________a compound that induces or activates transcription, such as lactose.a. Repressorb. Operator c. Promoterd. Corepressore. Inducer

Answers

Answer:

A repressor is a regulatory protein that may bind DNA to inhibit transcription. An operator is a DNA sequence that binds a regulatory protein. A promoter is a DNA sequence that binds RNA polymerase and regulates transcription. A corepressor is a compound that interacts with another protein or compound to form an active repressor. An inducer is a compound that induces or activates transcription, such as lactose.

Explanation:

Repressor proteins bind to DNA and RNA to suppress target gene expression. A DNA repressor blocks transcription by inhibiting the attachment of RNA polymerase to the promoter sequence, while an RNA repressor bind to the mRNA to block translation of the protein. An operator is a DNA sequence required for the attachment of transcription factors. The genes that are transcribed by the binding of a transcription factor to an operator sequence are collectively referred to as an operon. Operons are generally found in prokaryotes but they also can be found in some eukaryotes including Caenorhabditis elegans and Drosophila melanogaster. An inducer is a molecule that activates gene transcription either by binding to repressors/corepressors (thereby inactivating their functions) or by binding activators. For example, the allolactose act as an inducer of the lac operon.

When the body cells are hypotonic to the blood plasma, water will move from intracellular fluid to extracellular fluid.
A. True
B. False

Answers

Answer:

True

Explanation:


is the basic unit of structure and function of living things.

Answers

Answer:

cells

Explanation:

is the basic unit of life :)

If bacteria transformed with a recombinant pUC18 plasmid produce white colonies when grown on plates containing ampicillin and Xgal, which of the following is least likely?

a. They produce β-lactamase that provides resistance to ampicillin.
b. They carry a vector that contains a DNA fragment inserted into the multiple cloning site.
c. They produce functional β-galactosidase that cleaves X-gal.
d. They carry a vector with a lacZ gene that has been disrupted and rendered nonfunctional.
e. They carry a vector with the bla gene used as the selectable marker.

Answers

Answer:

c. They produce functional β-galactosidase that cleaves X-gal.

Explanation:

β-galactosidase is an enzyme capable of catalyzing the enzymatic hydrolysis of β-galactosides into monosaccharides by hydrolyzing the β-glycosidic bond. On the other hand, X-gal is an analog of lactose composed of galactose, which is widely used in laboratories for the detection of β-galactosidase. In the presence of β-galactosidase, X-gal is hydrolyzed by cleaving its β-glycosidic bond, thereby confirming the presence of β-galactosidase.

Why are G proteins known as guanine nucleotide-binding protein?

Answers

Answer:

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. ... G proteins belong to the larger group of enzymes called GTPases.

the origin of a muscle is generally

Answers

explain the  question more

Answer: The stable and proximal attachment

Explanation:

(06.03 LC) Which of the following is an example of how HIV can be transmitted from one person to another? Contact between infected blood and a mucus membrane Contact between infected saliva and an open wound Contact between infected blood and skin Contact between infected saliva and lining of mouth

Answers

Answer:

i believe the answer is contact between a infected blood and a mucus membrane

Explanation:

An sixty-year-old man has painful fluid-filled vesicles that have begun crusting over in a wide band across the left side of his lumbar area. He has a history of chickenpox. Based on this information, the likely disease is which is caused by:________

a. scabies, Pediculosis humanus
b. fever blisters, HSV-1
c. impetigo, Staphylococcus aureus
d. German measles, Rubella
e. shingles, varicella-zoster virus

Answers

Answer: shingles, varicella-zoster virus

Explanation:

It should be noted that shingles usually occur with old people and it causes a painful rash when the chicken pox virus is reactivated in the body.

Since the man is old and has painful fluid-filled vesicles that have begun crusting over in a wide band across the left side of his lumbar area and also has a history of chickenpox, it's very likely it is shingles.

In the image, the arrow Is pointing to a celestial object. Which attribute disqualifies the object from being a planet?
A. It appears to have no moons.
B. It is spherical in shape.
C. Its neighborhood is not clear.
D. It has horizontal bands on its surface.

Answers

The correct answer is C. Its neighborhood is not clear.

Explanation:

One of the key features of a planet is that it clears its neighborhood; this means the planet gravitational force is strong enough that there are no other celestial bodies on its orbit or next to it except by its moons or satellites. This does not occur in the image presented because there are smaller celestial bodies near to the main or bigger celestial body. This likely occurs if the celestial body is not big enough to clear its neighborhood, and therefore it is not a planet.

A mutation that hides the effect of another mutation at a site that is distinct from the site of the original mutation, but with in the same gene. This mutation is best described as a

Answers

Answer:

The correct answer is intragenic suppressor mutation.

Explanation:

A suppressor mutation partially or completely converses the effects of a different mutation. A suppressor mutation is of two kinds, that is, an intragenic suppressor and an intergenic suppressor. An intragenic suppressor converses the influence of a mutation at a distinct site in a similar gene.  

On the other hand, an intergenic suppressor converses the influence of a mutation at a distinct locus of the gene. It is the intragenic suppressor mutation, which takes place in a similar gene where the occurrence of the first mutation had taken place. Therefore, the mutation, which hides the influence of another mutation at a location, which is different from the location of the original mutation, but taking place in a similar gene can be illustrated as the intragenic suppressor mutation.  

QUICKLY! The chemical reaction equation of photosyntesis is shown here: What information is not given in this equation. It does not show if the reaction is reversible. It does not show the reactants needed for the reaction. It does not show that photosynthesis consists of many separate steps. It does not show the number of molecules required to produce glucose.

Answers

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

Photosynthesis is a unique process carried out by the cells of autotrophic organisms. It is the process whereby they synthesize their own food in form of sugars (glucose) in the presence of sunlight. Ideally, the photosynthetic process makes use of carbon dioxide (C02) and water (H20) in the presence of light energy (from sun) to produce glucose sugar (C6H12O6) and oxygen (02). The general photosynthetic equation is as follows:

6CO2 + 6H20 + light → C6H12O6 + 6O2

However, the process is not as simple as portrayed as it involves many separate steps that collectively forms the photosynthetic product (glucose). Photosynthesis occurs in two major stages namely: light stage and light independent stage, which in turn consists of series of reactions that forms the products.

Therefore, the equation attached to this question describes photosynthesis but It does not show that photosynthesis consists of many separate steps.

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

If a person had not drunk any water for 8 hours before collecting a sample, would you expect his/her urine to have a high or low specific gravity? Why?

Answers

Answer:

The person’s urine will have a high specific gravity

Explanation:

A high specific gravity is characterized by an increased concentration of solutes in the urine of am individual. A low specific gravity is characterized by a low or decreased concentration of the solutes.This is usually due to dehydration as a result of environmental conditions or tedious physical activities.

This explains why a person who had not drank any water for 8 hours and is dehydrated before collecting a sample is thought to have a urine with a high specific gravity

A.While the traits studied in Exercise 1 were hypothetical genetic traits, what type of genetic traits do you think are important to study and predict

Answers

Answer:

Genetic disturbances harmful to the organism are genetic characteristics that must be studied and predicted.

Explanation:

Genetic disorders that harm an organism such as sickle cell anemia, hemophilia, Turner syndrome, among others, are important to be studied and predicted, because it will provide better maintenance of that organism. Allowing people who inherit these characteristics to have more efficient treatments and a better life, since the prediction of these characteristics allows the family to establish better adapapitativo methods, that will make the life of this individual easier and with more quality.

in the krebs cycle,

a. pyruvate is broken down into Co2 molecules
b. glucose is broken down into NADH and CO2
c. Co2 is concerted in pyruvate and O2
d. NADH and CO2 are converted into ATP

Answers

Answer:

a. pyruvate is broken down into Co2 molecules

Explanation:

Krebs cycle is also known as Citric Acid Cycle, in which pyruvate formed during the glycolytic is broken down into Carbon Dioxide (CO2) and Water (H2O).

Each pyruvate molecule is broken down into carbon atom which releases carbon dioxide.

Hence, the correct answer is "a. pyruvate is broken down into Co2 molecules".

Choose only one correct option. Explanation needed.

Answers

Answer: D

only green plants

Answer:

[tex]\large \boxed{\mathrm{D. \ Photosynthesis}}[/tex]

Explanation:

Photosynthesis is a characteristic present in plants. Photosynthesis is a process where plants transform light energy into chemical energy. Reproduction, respiration, and excretion are all characteristics of living organisms.

I need help with this

Answers

Answer:

I know the answer

Explanation:

Yes

Yes

Yes

Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome. If a researcher moves the repressor gene (lacI), along with its promoter, to a position at some several thousand base pairs away from its normal position, which of the following results would be expected?
A) The repressor will no longer bind to the operator.
B) The repressor will no longer bind to the inducer.
C) The lac operon will be expressed continuously.
D) The lac operon will function normally.

Answers

Answer:

D) The lac operon will function normally.

Explanation:

The promoter area can be described as the area that causes the transcription to initiate for a particular gene. Promoters may be near the genes from which they initiate transcription or they may display multiple scenes upstream. The lock operon works normally because the promoter area can still enable transcription on many base pairs. Detects repression promoter and works normally.so correct option is D) The lac operon will function normally.

If a researcher moved the repressor gene of lac I, along with its promoter; the lac operon will function normally. Option D is correct.

Promotor:

It is the genetic sequence that is recognized by the RNA polymerase to start the transcription.

Here, researcher moved the repressor gene of lac I , along with its promoter.

Therefore, transcription starts, it will express the repressor gene also because repressor gene was moved with promotor.

To know more about Lac operon,

https://brainly.com/question/4109690

What complications might arise from genetic screens targeting an organ that differentiates late in development?

Answers

Answer:

No sign of testicular development in boys and breast development in girls.

Explanation:

Complications like no sign of testicular development in boys and breast development in girls occurs if an organ develop very late. There are many causes of this type of complications such as long term illness, eating improper food and disorder of sexual development. Sometime these complications  also occurs due to genetically. These complications should be treated well with medication and use of nutritious food. These medicines increases the performance of sex hormones in order to initiate puberty.

Which conclusion can be drawn from the experimental observation that a single strand of DNA contains 2100 dA residues and 1800 dT residues?

Answers

a. There must have been some loss of material in the extraction because the number of dA and dT residues must be the same.

b. This is a palindromic sequence.

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

d. This must be prokaryotic DNA

e. None of these

Answer:

c. There must be 2100 dT and 1800 dA residues on the complementary strand.

Diatoms are mostly asexual members of the phytoplankton. Diatoms lack any organelles that might have the 9 + 2 pattern. They obtain their nutrition from functional chloroplasts, and each diatom is encased within two porous, glasslike valves. Which question would be most important for one interested in the day-to-day survival of individual diatoms?A) How does carbon dioxide get into these protists with their glasslike valves?B) How do diatoms get transported from one location on the water's surface layers to another location on the surface?C) How do diatoms with their glasslike valves keep from sinking into poorly lit waters?D) How do diatoms with their glasslike valves avoid being shattered by the action of waves?E) How do diatom sperm cells locate diatom egg cells?

Answers

Answer:

Diatoms are mostly asexual members of the phytoplankton. Diatoms lack any organelles that might have the 9 + 2 pattern. They obtain their nutrition from functional chloroplasts, and each diatom is encased within two porous, glasslike valves. Which question would be most important for one interested in the day-to-day survival of individual diatoms?

C) How do diatoms with their glasslike valves keep from sinking into poorly lit waters?

Explanation:

Diatoms are some of the most important organisms living on earth because of its role on the oxygen production in the planet earth. The question "how do diatoms with their glasslike valves keep from sinking into poorly lit waters?" Because of the way their nutrition is obtained from functional chloroplasts and the way them encased within two porous, glasslike valves.

What does cyclical mean

Answers

Cyclical means occurring in cycles technically meaning reoccurring.

Which location is least likely to experience a volcanic eruption? Α. an island hot spot, such as the island of Hawaii B. Hamilton County on the plains of central Texas с. a convergent boundary, as in the Ring of Fire D a volcanic island arc, such as the Aleutian Arc in Alaska

Answers

Answer:

i think that the answer is B. Hamilton County on the plains of central Texas i took the test

Explanation:

Hamilton County on the plains of central Texas is least likely to experience a volcanic eruption. Therefore, option (B) is correct.

What are volcanoes?

Molten rock and gases stored under the surface erupt through a volcano, generating a hill or mountain.

Active, inactive, or extinct volcanoes. Active volcanoes are likely to erupt again. Dormant volcanoes may erupt again. Extinct volcanoes won't erupt.Magma collects inside active volcanoes. The magma chamber's pressure forces it through rock channels and onto the planet's surface.

Volcanic eruptions can be violent or slow-moving. Volcanoes erupt through vents on the sides or a primary entrance at the top. The volcano's morphology depends on eruption rate and magma chemistry. Land and sea volcanoes exist. As lava cools and hardens, underwater volcanoes build mountains and ranges. When volcanoes rise above the ocean, they create islands.

Learn more about volcano, here:

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What is the correct formula for population growth? A. D+B-I-E B. E+D-B-I C. B+I-D-E D. I+E-B-D

Answers

Answer:

C.) B+I-D-E

Explanation:

The correct formula for population growth is the individuals added to the population via birth or immigration, minus the individuals removed from the population via death or emmigration. Therefore the answer is (B+I)-(D+E), or B+I-D-E

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