Which of the circumstances below most accurately describes conditions that are likely to permit a robust anti-tumor adaptive immune response?

a. A tumor with high expression of proteins that have mutations in sequences encoding HLA-binding peptides.
b. A robust acute inflammatory response to PAMPs expressed specifically by tumor cells.
c. Anti-tumor T lymphocytes that have high expression of CTLA-4.
d. A tumor with high expression of PD-L1.

Answers

Answer 1

Did you ever figure out the answer to this question?

Answer 2

The study of PAMP-DAMP complexes is vital to the advancement of knowledge regarding inflammatory disorders in general and cancer in particular. Therefore, option (B) is correct.

What is PAMP-DAMP complexes?

Increasing evidence links inflammation to cancer, and at the root of inflammation are PAMPs and DAMPs (DAMPs). Microorganisms contain PAMPs, which are detected by pattern recognition receptors on monocytes and DCs (PRRs). PRR activation produces pro-inflammatory cytokines.

A robust immune response requires endogenous chemicals that pose 'risk' to self-tissues and are created by injured or stressed cells; these are DAMPs, which also trigger inflammation. PAMPs and DAMPs each have about 100 receptors. PAMPs and DAMPs interact; a PRR can bind to both. In this system, PAMPs and DAMPs affect each other's activation threshold. Thus, PAMP-DAMP relationships describe inflammation in a predictable 'inflammatory code'

PAMP-DAMP complexes are key to understanding inflammatory disorders and cancer.

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Related Questions

4. Unlike a scientific theory, a scientific law describes an observed pattern in nature without
attempting to explain it.
O true
Ofalse​

Answers

Answer:

False

Any discovery must first be tested and have an explanation

Choose a strategy to clone genes known only by a mutant phenotype in organisms with highly efficient transformation procedures and relatively small genomes.

Answers

Answer:

By combining traditional genetic mapping with whole-genome sequencing (next-generation sequencing)

Explanation:

Map-based cloning, also named positional cloning, is a technique used to identify genetic sequences linked to markers whose exact physical localization in the genome is known. Map-based cloning has shown to be useful to clone genes, however, this approach is limited to the existence of mutant phenotypes in different organisms/accessions/strains. In recent years, map-based cloning has been combined with next-generation sequencing methodologies in order to clone genes in background of single mutants without information on multiple organisms. This type of strategy has the potential for identifying causal mutations and thus clone genes in species with small genomes and high transformation efficiencies such as, for example, Arabidopsis thaliana.

Which of the following can a chemical bond do?
A. Change element properties
B. Store energy
OC. All of these
D. Release energy

Answers

Answer: C

Explanation:

The following can a chemical bond do is all of these. The correct option is C. All of these.

What is a chemical bond?

A chemical bond is a bond formed between two elements. The energy of the reaction is stored in the bonds when the reaction happens, the energy is released from the bonds. It also changes the chemical properties of the elements.

Thus, the correct option is C. All of these.

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A response to an unconditioned stimulus that occurs naturally without learning is known as a(n) __________ response.
A. neutral
B. conditioned
C. reconditioned
D. unconditioned

Answers

Answer:

it is going o be B. conditioned

Answer:

D

Explanation:

edge

Predict what will happen to the following lung volumes and capacities during strenuous exercise. Assume that you are comparing from a baseline of normal resting respiration.


Lung Volume or Capacity Predicted change from resting baseline : Use Increase, Decrease or No Change

TLC (total lung capacity)
No change
VC (Vital capacity)
IC (Inspiratory capacity)
FRC (Functional residual capacity
TV (Tidal volume)
IRV (Inspiratory reserve volume)
ERV (Expiratory reserve volume)
RV (Residual volume)

Answers

Answer:

During intense exercise:

lung capacity increases

vital capacity increases

respiratory capacity increases

functional residual capacity increases

tidal volume increases

the inspiratory and expiratory reserve volumes decrease as does the residual volume.

Explanation:

Residual volumes decrease because having better lung capacity, better development of the secondary skeletal muscles that collaborate in expiration and inspiration, these are given in a better way, and more effectively.

If these processes take place more efficiently, their potentiality increases and expiration and inspiration move a large current of air into the lungs, thus leaving less reserve airs.

Those people who have increased exhalation or inspiration reserve, have a weak activity of the musculature in the processes and function as "stagnant air" which is synonymous with a lack of physical activity or aerobic capacity.

It is important to clarify that all the above processes are accompanied by an increase in the size of the chest cage

How does the movement of particles of matter change when temperature increases?
Decreases
Increases
Increases then decreases
Does not change

Answers

Answer:

Increases

Explanation:

The movement of particles of the matter increases with the increase in temperature.

The particles gain kinetic energy with increasing temperature and move in faster rate.

For example: When we blow a balloon with our mouth, we increases the temperature inside the balloon, the particles in the balloon gain kinetic energy that leads to the faster movement of gas particles in the balloon and they collide with each other and surface of balloon, after a peak the balloon get burst because of high kinetic energy and high collision.

Hence, the correct answer is "increases".

the origin of a muscle is generally

Answers

explain the  question more

Answer: The stable and proximal attachment

Explanation:

if a person who is blood type O marries a person who is blood type A, what are the possible blood types their children could have

Answers

Answer:

The possible blood types their children could have are A or 0.

Explanation:

  The I gene determines the blood type of a person. I is the dominant allele, while i is the recessive allele.

IA dominant over i. The person presents A type of antigens. IB dominant over i. The person presents B type of antigens. IA and IB are codominant. The person presents both types of antigens, A and B. i is the recessive allele. The person does not present any antigen.

Cross: a person who is blood type O with a person who is blood type A

Parental)    ii      x     IA-

Gametes) i   i          IA   -

Punnet Square)   IA            -

                     i      IAi           -i

                     i      IAi           -i

The - symbol represents the possibility of either IA allele or i allele. This is, the parental with blood type A might have the genotype IAIA or IAi

F1)  2/4 = 1/2 IAi

     2/4 = 1/2    -i  (-i could be either IAi or ii, depending on the genotype of the parental with blood type A)

Option 1: ii  x  IAIA

F1)  100% IAi (The whole progeny will have blood type A)

Option 2: ii  x  IAi

F1) 50% IAi (Half of the progeny will have blood type A)

    50% ii (Halfa of the progeny will have blood type 0)  

The possible blood types their children could have are A or 0.

In the DNA isolation process, cells are mixed with sodium chloride (i.e. NaCl) because the sodium (Na ) neutralizes the negative charge of DNA.

a. True
b. False

Answers

Answer:

this is true it neutralise easily

It is true that in the DNA isolation process, cells are mixed with sodium chloride (i.e. NaCl) because the sodium (Na ) neutralizes the negative charge of DNA.

What is DNA isolation?

DNA extraction is a method of separating DNA from cell membranes, proteins, and other cellular components using physical and/or chemical methods from a sample. In 1869, Friedrich Miescher isolated DNA for the first time.

The ability to extract DNA is critical for studying the genetic causes of disease and developing diagnostics and drugs.

It is also required for forensic science, genome sequencing, detecting bacteria and viruses in the environment, and determining paternity.

Because sodium (Na+) neutralizes the negative charge of DNA, cells are mixed with sodium chloride (i.e. NaCl) during the DNA isolation process. It makes homogenization easier.

Thus, the given statement is true.

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After the centromeres separate during mitosis, the chromatids, now called _______, move toward opposite poles of the spindle.

Answers

Answer:

Daughter chromosomes

Explanation:

Which of the following is a testable scientific question

Answers

Where are the questions so i can answer them?

Answer: Just took the test: Its "How does the age of city affect the number of trees in the city? "

Where does that air go as a result?

Answers

Answer:

Air go from one place to another due to difference in temperature of land and sea.

Explanation:

Air go as a result of wind from one place to another. Air moves from land to sea is called land breeze and from sea to land is known as sea breeze. This will occur when there is difference in temperature between sea and land. Sea breeze occurs at afternoon while land breeze occurs at night till morning. Warm air produces low pressure and cold air produces high pressure so when warm air rises, cold air takes its place and this cycle continues.

If you insert a gene from bacteria into a mouse genome, then which terms best explains what you just made?

Answers

Answer:

a transgenic animal

Explanation:

Which structures are highlighted? Which structures are highlighted? pulmonary arterioles alveoli bronchioles pulmonary capillaries

Answers

Hello. You forgot to put the image that complements this question. The image is attached below:

Answer:

pulmonary arterioles

Explanation:

Pulmonary arterioles are small blood vessels located in the lung. They appear as branches of the major arteries and have the main function of releasing blood from capillaries, in addition to regulating blood flow and peripheral blood pressure in capillaries.

It is important to note that arterioles are very small in size, which facilitates their functions to be performed efficiently and quickly.

Which organisms transform nitrogen to a form that is useful to plants?
bacteria
animals
fungi
humans​

Answers

Answer:

Bacteria

Explanation:

Nitrogen fixation is the step of the nitrogen cycle that occurs with the help of microbes. Bacteria transform the nitrogen into a usable form for the plants. Thus, option a is correct.

What are nitrogen-fixing bacteria?

The nitrogen cycle is the part of the biogeochemical cycle that converts nitrogen into other forms that can be used by plants. The nitrogen is converted through the nitrogen-fixing bacterias.

The nitrogen-fixing bacterias are heterotrophic in nature that lives freely in the soil. A few examples are Bacillus, Azotobacter, Clostridium, etc. These bacterias transform the atmospheric nitrogen into usable compounds called ammonia which is the fixed nitrogen and can be used by the plants.

Therefore, nitrogen-fixing bacterias transform nitrogen.

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Explain what, if any, is the issue facing DNA polymerase in regards to its 5’->3’ activity when replicating DNA.

Answers

Answer:

The two strands of DNA are replicated in different ways

Explanation:

DNA replication is a process that occurs during the S phase of the cell cycle that consists of making two identical copies of the double-stranded DNA molecule, which subsequently are distributed in the daughter cells during cell division. During this process, DNA polymerase can add nucleotides in 5' to 3' direction, but not in 3' to 5' direction. In consequence, the DNA strand that has 3’ to 5’ directionality can be synthesized directly, while the DNA template strand that has 5’ to 3’ directionality can't be synthesized in a continuous manner and thereby it is created by adding small DNA fragments, which are known as Okazaki fragments (150-200 nucleotides in size).

The ion composition of perilymph is like that of interstitial fluid; high sodium and low potassium levels. If someone ruptured the vestibular membrane, the membrane between the vestibular duct (Scala vestibuli) and the cochlear duct (Scala media), what would be the effect of such a rupture on the concentration of potassium in the endolymph in the cochlear duct

Answers

Answer:

The concentration of potassium will decrease

Explanation:

The cochlear ducts are composed of two distict types of fluids: 1-perilymph, rich in sodium (140 mM) and low in potassium (5 mM), and 2- endolymph, rich in potassium (1 mM) and low in sodium (150 mM). The perilymph fluid has a similar composition to the rest of the extracellular fluids, while endolymph present a unique ion composition that is not found in other fluids of the body. It is believed that the cochlea can regulate potassium flow without using energy (i.e.,  without use ATP), since potassium enters into the cells through passive pathways, while this ion ion leaves the cells by an active mechanism.

Provide one example of quantitative data that can be collected when using a microscope?

Answers

Answer: there 3 ducks by the pond

Explanation:

Quantitative is numbers. how many.

fur color in mice is affected by a single gene the gene for fur color has two alleles: b that causes dark brown fur and b that causes light brown fur. What is or could be the genotyes of a mouse with dark brown fur

Answers

Answer:

(BB) or (Bb)

Explanation:

Given that (B) allele , is responsible for fur that is dark brown, and (b) allele is responsible for fur color that is light brown, the dominant allele is (B) allele for dark brown fur. Dark brown fur allele would always express itself over the recessive allele, (b).

For a mouse that has dark brown fur, the possible genotype it could have is either (BB) => 2 dominant allele, or (Bb) => 1 dominant allele and a recessive allele. The dominant allele would always express itself even in the presence of the recessive allele.

Alexei Romanov suffered from hemophilia, a condition that (1 point)
causes the body to produce too many blood cells due to the body's inability to form fibrin proteins.
o prevents blood from clotting normally due to the body's inability to form fibrin proteins.
O causes the body to produce abnormally shaped red blood cells due to the body's inability to form fibrin proteins.
o prevents the body from absorbing vitamin B12 due to the body's inability to form fibrin proteins.

Answers

Answer:

prevents blood from clotting normally due to the body's inability to form fibrin proteins.

Explanation:

Haemophilia is a genetic disorder which could be inherited and it is characterized by constant bleeding and loss of blood when injuries occur. This is as a result of the inability of the body to form fibril proteins. The fibril proteins are responsible for the production of platelets . The platelets are responsible for the clotting of blood.

This validates haemophilia being a disorder which prevent blood from clotting normally due to the body's inability to form fibrin proteins.

For those who need more answers

1. Adenine

2. Prevents blood from clotting normally due to the bodys inability to form fibrin proteins

3. TCA

4. DNA has the sugars deoxyribose, while RNA has the sugar ribose

5. tRNA carries amino acids to the ribosome and helps form proteins

A class is debating pros and cons of using sea walls to reduce beach erosion. What is the best way for them inform their
decision-making?

They should each write an opinion paragraph to send to the local paper.

They should hold the debate on stage, so that they can be judged.

They should watch movies about beaches.

They should research wave action and collect data about erosion in the area.

Answers

Answer:

They should research wave action and collect data about erosion in the area.

Explanation:

everyone has their own opinion, and movies aren't gonna make the cut, and no one wants to see a debate in school, so they should research first to get the info they need

Which of these statements most accurately describes currencies in North America

Answers

Answer:

North American countries have done away with separate currencies. Each country in North America uses its own currency. 2. See ...

The lactic acid generated in the body of a cricketer is first converted to glycogen in 1) Muscles 2) Liver 3) Blood 4) Both 2 and 3

Answers

Answer:

2) liver

Explanation:

the bloods transports the lactic acid to the liver to be converted into glycogen

chapter 1 in microscope biology​

Answers

Answer:

100*

Explanation:

it is a bacteria which needs to be seen under a strong microscope.

In humans, insulin is manufactured in the pancreas, insulin is a peptide hormone that causes the body’s cells to take up glucose. The blueprint for the polypeptide chain that is insulin is found in the — of specialized pancreatic cells.

Answers

Answer:

In type 1 diabetes the immune system erroneously attacks the beta cells that produce insulin in your pancreas. It causes permanent damage, leaving your pancreas unable to produce insulin. Exactly what triggers the immune system to do that isn't clear. Genetic and environmental factors may play a role.

Explanation:

Nucleic acids

Composed of Carbon, Hydrogen, Oxygen, Nitrogen and phosphorous.

DNA

The universal code that stores genetic information in all organisms

Semi

conservative-Bases in original strand split and new nucleotides complementary base pair to form two new strands

Mutations

Any change to the DNA sequence

Gene mutation

Permanent change in the DNA sequence that makes up a gene.

Transcription

The process of copying a nucleotide sequence of DNA to form a complementary strand of mRNA

Translation

Process by which mRNA is decoded and proteins are made.

Codon

Three nucleotide bases

tRNA

Reads the codon on the mRNA using anticodons and the complimentary base pair rules and delivers the amino acids

What would be the replicated DNA strand for the following DNA sequence?...GCGTATG

CGCATATC

What would be the mRNA and tRNA be for the following DNA sequence?...AGGTTA

mRNA...UCCAAU. tRNA...AGGUUA.

The process of converting the genetic message from DNA into ____ is called transcription.

mRNA

How many amino acids are in the human body and what do we call the bond that holds them together?

20; Peptide bond

A single strand of DNA contains the following nine nucleotides in order ACTTATGGA. What sequence of bases will be present on the complementary strand of DNA?

TGAATACCT

In humans, insulin is manufactured in the pancreas. Insulin is a peptide hormone that causes the body's cells to take up glucose. The blueprint for the polypeptide chain that is insulin is found in the __________ of specialized pancreatic cells.

DNA

Given the sequence of DNA nucleotide bases TTAGCCTTG, give the complementary mRNA produced during transcription.

AATCGGAAC

Identify the correct sequence of molecules, as a gene goes from coded information in the nucleus, to the product the cell wants to make.

DNA...messenger RNA...transfer RNA...Protein

Why is DNA replication considered semiconservative?

Each half of the old DNA strand serves as a template for the new growing strand causing the copied DNA to half new and half old.

who is the father of Genetic​

Answers

Answer:

hey there

Explanation: answer is gregor mendal  is the father of genetic in 19th century.

Answer:

Gregor Johann Mendel

Acidification of the stomach uses all of the following types of transport EXCEPT: A. channels. B. pumps. C. antiporters. AND. symporters. E. All of these are used by parietal cells.

Answers

Answer: Option E.

All of these are used by parietal cells.

Explanation:

Parietal cells are found in the stomach and they produced gastric acid(Hcl)..

HCl is produced when water mixed with carbondioxide in the parietal cell to produced carbonic acid which is catalyses by carbonic anhydrase. The carbonic acid then dissociates into hydrogen ion and carbonate ion.

Parietal cell produce HCl due to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (gastrin receptors).

Therefore it uses channels, pumps, antiporter.

Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome. If a researcher moves the repressor gene (lacI), along with its promoter, to a position at some several thousand base pairs away from its normal position, which of the following results would be expected?
A) The repressor will no longer bind to the operator.
B) The repressor will no longer bind to the inducer.
C) The lac operon will be expressed continuously.
D) The lac operon will function normally.

Answers

Answer:

D) The lac operon will function normally.

Explanation:

The promoter area can be described as the area that causes the transcription to initiate for a particular gene. Promoters may be near the genes from which they initiate transcription or they may display multiple scenes upstream. The lock operon works normally because the promoter area can still enable transcription on many base pairs. Detects repression promoter and works normally.so correct option is D) The lac operon will function normally.

If a researcher moved the repressor gene of lac I, along with its promoter; the lac operon will function normally. Option D is correct.

Promotor:

It is the genetic sequence that is recognized by the RNA polymerase to start the transcription.

Here, researcher moved the repressor gene of lac I , along with its promoter.

Therefore, transcription starts, it will express the repressor gene also because repressor gene was moved with promotor.

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In the quest to understand the basis of infertility in humans, researchers have identified a mutation in a gene associated with chiasmata. This protein normally acts to promote homologous recombination.Why might a defect in homologous recombination have consequences for fertility?A. The chiasmata halts the whole process of meiosis, if crossover do not form properly.B. Crossover formation is a necessary step in meiosis I to ensure proper chromosome segregationC. A checkpoint requires a certain level of genetic variability for meiosis to proceed.D. Chiasmata are the connections between the centromeres and the centromeres that pull them to each pole of the daughter cells.

Answers

Answer:

B. Crossover formation is a necessary step in meiosis I to ensure proper chromosome segregation

Explanation:

Crossing-over is a unique phenomenon that occurs in the prophase I stage of meiosis I, where non-sister chromatids of homologous chromosomes exchange their chromosomal segment. The physical point where this exchange occurs is called CHIASMATA. Hence, a mutation that affects the gene associated with the chiasmata will affect the occurrence of crossing over or homologous recombination.

Crossing-over, through the formation of the chiasmata, is responsible for the physical alignment and proper segregation of chromosomes into gametes. Naturally, the chiasmata formed as a result of recombination during meiosis helps ensure that the chromosomes stay together until it is the right time to separate. This way, any chromosomal defect in the resulting gamete is prevented.

However, an error or defect in homologous recombination might give rise to gametes with chromosomal disorder, a condition known as ANEUPLOIDY i.e. missing or additional chromosomes in gametes. This can affect the fertility of the involved human.

Which of the following best describes how crossing over occurs during meiosis?

Answers

Answer:

first give the following options bro..

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Read the sentence. Crafts once fulfilled useful purposes, now crafts are used mainly for decoration. Which revision most effectively corrects the comma splice? ( 2x - 9) x ( x + 5 ) Audrey is suffering from depression that was triggered by a breakup with her boyfriend. She tells her therapist that no man will ever love her. Her therapist challenges the validity of her belief by stating that just because one person broke up with her doesn't mean that all of her relationships will fail. The therapist then has Audrey make a list of all the guys she knows who would probably go out with her on a date. To her surprise, Audrey is able to name a handful and realizes that her belief that no one will love her probably is distorted by the emotional pain from her breakup. Audrey's therapist is using: PLEASE HELP!!Solve for ya) 8b) 12c) 3V7d) 4V7 A function of random variables used to estimate a parameter of a distribution is a/an _____. A. unbiased estimator B. statistic C. predictor D. sample value Find the odd one out a)Planets moving on it's axis,Strings of guitar (being played),Motion of a ferry wheel,The vehicles moving on a straight road. b)Motion of the moon around the earth,Motion of the earth around the sun,Motion of a merry-go-round,Heart-beat in a healthy person. c)Motion of a bullet fired from gun,Motion of a football player in the ground,Motion of a vehicle on a straight road,Motion of an apple falling from a tree 5 . pls ANSWER This question. very urgent. A baby weighs 100 ounces. Find the baby's weight in pounds and ounces. El siguiente diagrama A, B, C, D, E, F denotan islas, y las lneas de unin son puentes. El hombre empieza en A y camina de isla en isla. El hombre no puede cruzar el mismo puente dos veces. Hallar el nmero de maneras que puede hacer su recorrido antes de almorzar.A-B-C-D E-FA esta conectado a B, B a C y C a D. B est conectado a E, C esta conectado a F y hay una linea que conecta E y C For which of the following compound inequalities is there no solution? A. 3m - 12 > 30 and -6m >= 24 B. -6m >= 12 and m + 5 -18 C. -5m < 20 and 6m > -18D. -4m - 10 = 22>= is greater than or equal to We discussed the different types of intermolecular forces in this lesson, which can affect the boiling point of a substance. 1. Which of these has the highest boiling point?A) ArB) KrC) XeD) Ne2. Which substance has the highest boiling point?A) CH4B) HeC) HFD) Cl2 What is the magnitude of the applied electric field inside an aluminum wire of radius 1.4 mm that carries a 4.5-A current find the roots of the following equation X + 1 whole square minus x square equal to 2 Find the value of x in each case: i)Briefly discuss the strengths and weaknesses of the four spectroscopy techniques listed below. Include in your answer the specific structural information you get from each method.IRUV-VISNMRMass Spec Gabriel, Harris and Ida are members of Jeweled Watches, LLC. What are their options with respect to the management of their firm? Why does it typically cost more money to win a seat on the Texas Supreme Court than a seat on the Texas court of criminal appeals? The Texas legislature has placed a strict cap on the spending for criminal appeals court election campaigns. There are few interest groups that contribute money to the criminal appeals court candidates campaigns, which keeps down the costs of the election. Judges running for the criminal appeals court do not have to be elected in a statewide election. Fewer people are interested in the court of criminal appeals. What predictable body of water was both a source of prosperity also caused damaging floods forthe Egyptian civilization?the Nile Riverthe Tigris RiverThe Amazon Riverthe Euphrates River Banc Corp. Trust estimates that it costs $500 to analyze and close a commercial loan. This amount has been included in the $396,000 of overhead costs. How much of the remaining overhead costs should be allocated to the Consumer Department? Given the graph, find an equation for the parabola.