In 2012, excitement rippled through the scientific community with the discovery of an enzyme that appeared to be, just maybe, a powerful new tool for combating Alzheimer’s. At the Mayo Clinic in Florida researchers identified a gene, BACE2, which appeared to destroy beta-amyloid — a protein, then understood to be toxic, which is found in clusters in the brains of people living with Alzheimer’s. Alzheimer's is often diagnosed by measuring the amount of buildup of this protein. A large amount of it is an indicator of the disease. People with this buildup often do not have enough of the BACE2 enzyme created naturally in their body. If a way to synthesize this enzyme artificially or to prompt the body to create more were discovered, it could be hailed as a cure for Alzheimer's. How does the BACE2 enzyme work?

Answers

Answer 1

Answer:

BACE2 cuts both beta-amyloid and beta-amyloid precursor protein.

Explanation:

What makes BACE2 so effective in fighting Alzheimer's is its efficiency in cutting both beta-amyloid and the protein that develops it. There are other enzymes, which have the ability to break down beta-amyloid, but BACE2 is the only one that breaks it down into such small pieces that it completely destroys it. Furthermore, BACE2 is able to break down the beta-amyloid precursor protein, which prevents the formation of beta-amyloid from taking place.


Related Questions

Tetrodotoxin is a potent toxin found in a variety of organisms including the pufferfish. The toxin binds to the extracellular side of the Na+ channel and prevents channel opening. This leads to paralysis of muscles, including the diaphragm. Death from respiratory failure can occur after ingestion of as little as 1 mg of the toxin. Why does this toxin cause paralysis? Question 7 options: The axon membranes become over-depolarized. The Na+ channels remain in the inactive, refractory state. The Na+ channel does not open wide enough to allow enough Na+ through the channel. The membrane depolarization is not amplified along the axon.

Answers

Answer:

The correct answer is - The membrane depolarization is not amplified along the axon.

Explanation:

Tetrodotoxin, a neurotoxin present in the liver and gonads of Marine organisms. it can inhibit the soidum channels which means it blocks the entering of the sodium in the cells or neurons if consumed it and it can lead to neurological and gastrointestinal disorders.

These toxins block the signals to move along the nerves to muscles In absence of sodium action potential cannot be sent along the axon by blocking the sodium channels. This results in weakening and paralysis.

What stage of photosynthesis uses
carbon dioxide to make glucose?
A. Light reactions
B. Calvin Cycle
C. ATP synthesis
D Cellular respiration

Answers

Answer:

light reaction because glucose is a factor of sugar.

What is the evidence of variation when individuals in a population or group differ in some trait of interest

Answers

Answer:

When the more dominat trait starts to show up in most of the population while keeping the specis the same. This can be very benifitial to the population or harmful depending on the trait that is getting passed down.

Explanation:

Charles Darwin and Alfred Russel Wallace figured out that ____ influences the course of random evolution?
A. Dog breeders

B. Natural selection

Answers

Answer:

B. Natural selection

Explanation:

Explaination:

Answer:

B. natural selection

Explanation:

Natural Selection: Charles Darwin & Alfred Russel Wallace. A visit to the Galapagos Islands in 1835 helped Darwin formulate his ideas on natural selection. He found several species of finch adapted to different environmental niches. The finches also differed in beak shape, food source, and how food was captured.

Why do plants need water, light, and carbon dioxide?

Answers

Answer;

these are used in photosynthesis altogether. light splits the water into hydrogen and oxygen. water is used to manufacture starch, soften the testa during germination, dissolve food as well. carbon dioxide is also used during photosynthesis.

Los animales toman del medio los materiales necesarios para sus actividades vitales. Estas funciones la realizan: A. El aparato circulatorio. B. El aparato circulatorio, digestivo y respiratorio. C. El aparato respiratorio. D. El aparato respiratorio y circulatorio.

Answers

Answer:

C. El sistema respiratorio.

Explicación:

El sistema respiratorio es un tipo de sistema en el que los animales toman del medio ambiente los materiales necesarios para sus actividades vitales. Los pulmones son el órgano principal del sistema respiratorio en el que el gas de oxígeno entra al cuerpo y se almacena en los pulmones a través de la inhalación. La hemoglobina que extrae el gas de dióxido de carbono de la célula lo desecha en los pulmones y carga el oxígeno necesario para el proceso de respiración. El dióxido de carbono se elimina de los pulmones mediante la exhalación.

Identify the resources that cannot be replenished within the average span one
human life.
Select 2 correct answers!!!

petroleum
natural gas
trees or plants
water

Answers

Answer:

Natural gas and petroleum

Explanation:

They are nonrenewable resources, whereas water and biomass are renewable.

Would appreciate Brainliest if this helped you! Have a great day!

Why did Gregor Mendel use peas in his experiments?
Peas grow very slowly.
Pea reproduction cannot be controlled.
Peas normally produce very few offspring.
Peas have characteristics that have two forms.

Answers

Answer:

He used peas because they are self pollinating,they grow fast,and they have many traits

Answer:

D. Peas have characteristics that have 2 forms

Explanation:

Edge 2022.

All of the following affect the temperature at which magma forms except what?

Answers

Viscosity is the only one that doesn’t affect the temperature at which magma forms

Except viscosity, all the other factors affect the temperature at which magma forms. Therefore, the correct option is D.

What is viscosity?

Viscosity can be defined as a measure of the fluid's resistance to flow. Magma can be defined as a very hot molten or semi-molten substance that is formed due to volcanic eruptions. They are responsible for the formation of the igneous rocks.

There are many factors that affect the temperature at which magma forms:

Pressure-increasing pressure can raise the melting temperature of rocks, while decreasing pressure can lower it.Composition of source material: The composition of the rocks in the mantle can vary depending on the location and geological history of the region. Presence of water: Water can lower the melting point of rocks, which can lead to the formation of magma.

But viscosity does not play any role in impacting the temperature at which magma forms. Therefore, the correct option is D.

Learn more about viscosity, here:

https://brainly.com/question/30263409

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The question is incomplete, but most probably the complete question is,

All the following affect the temperature at which magma forms EXCEPT

A. pressure

B. composition of source material

C. water

D. viscosity

Deforestation occurs when large Amounts of trees are cut down and not replaced which of the following would result from deforestation


A. Decrease carbon in the atmosphere
B. Increased carbon in the atmosphere

Answers

Answer:

The correct answer is (B).

Explanation:

Deforestation occurs when large Amounts of trees are cut down and not replaced, which of the following would result from deforestation...

Increased carbon in the atmosphere

This statement is true because when trees become less abundant, the amount of oxygen being released into the atmosphere by trees via photosynthesis.

The circumstance that would result from deforestation is the increased carbon in the atmosphere. Thus, the correct option is B.

What is Deforestation?

Deforestation may be defined as the process of cutting down or eliminating trees in large numbers from our surroundings. This activity generally happens due to industrialization, wood extraction, urbanization, etc.

When the number of trees remains less in the environment due to deforestation or any other activity, the level of carbon dioxide in the atmosphere typically rises.

This is because carbon dioxide is considered the reactant of photosynthesis that is utilized by the plants along with water in the presence of sunlight and converted into oxygen.

But when the number of plants decreases, the level of carbon in the atmosphere increases, and the level of oxygen in the atmosphere decreases.

Therefore, the circumstance that would result from deforestation is the increased carbon in the atmosphere. Thus, the correct option is B.

To learn more about Deforestation, refer to the link:

https://brainly.com/question/76446

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Nutrients in excessive amounts enter water systems, causing algal bloom.

Answers

Answer: Nutrient pollution is caused when too many nutrients, primarily nitrogen and phosphorus, are added to water bodies. The excess nutrients act as fertilizers, causing excessive algae  growth. It is common for nutrients to run off the land in urban areas, where lawn and garden fertilizers are used.

Explanation:

I explained in the top-

Hope it helps if it doesn't then whooops

Answer:

good question very good

39 In a DNA molecule, if 38% of the molecular bases are C(cytosine), what percent of the bases are T (thymine)?
(1) 12
(3) 38
(2) 24
(4) 62

Answers

12
Explanation:
cause double of 38 is 62 and subtract that from 100 is 24 and divided that by 2 is 12

Which population of organisms would be in greatest danger of becoming extinct? *
A. A population of organisms having few variations living in a stable environment.

B. A population of organisms having many variations living in a stable environment.

C. A population of organisms having few variations living in an unstable environment.

D. A population of organisms having many variations living in an unstable environment.

Answers

B is the correct answer

Which statement best describes energy entering the living world?

a) solar energy to chemical energy

b) chemical energy to solar energy

c) solar energy to heat energy

d) heat energy to solar energy

Answers

Answer:

a. solar energy to chemical energy

Answer:

A .Solar energy to chemical energy

Explanation:

What is phylogeny?
A. How species interact with each another

B. The study of cells.

C. How organisms are related through evolution.

Answers

Answer:

Hey mate......

Explanation:

This is ur answer......

C. How organisms are related through evolution...

Hope it helps!

Brainliest pls!

Follow me! :)

Answer:

C. How organisms are related through evolution.

Explanation:

Phylogeny is the organisms that are related through evolution.

What happens if a protein-digesting enzyme is mixed with starch solution?

Answers

Please mark brainliest

Answer:
it would produce fat as its base and starch is acidic

For reference check the link

https://opentextbc.ca/biology/chapter/15-3-digestive-system-processes/

Why is carbon so important for living things

Answers

Answer:

Organic compounds make up the cells and other structures of organisms and carry out life processes. Carbon is the main element in organic compounds, so carbon is essential to life on Earth. Without carbon, life as we know it could not exist.

Explanation:

Answer:

Carbon is the most important element to living things because it can form many different kinds of bonds and form essential compounds.

56:47 If you wanted to increase your muscular endurance, it would be important to participate in activities that __________. A. increase the size of the muscle cells and the amount of blood that is delivered to the muscle B. decrease the amount of fuel that the muscle can store and increase the time it takes for the muscle to contract C. increase the number of muscles and decrease the size of the muscle cells D. decrease the length of the muscle and increase the thickness of the muscle

Answers

Answer:

The correct answer is - A.  increase the size of the muscle cells and the amount of blood that is delivered to the muscle.

Explanation:

Muscular endurance is the ability of a muscle to do some work or exert force continuously and rapidly for a period of time. To increase muscular endurance no heavy exercise required by including exercises that can help in increasing the size of the muscle cells and the amount of blood that is delivered to the muscle. The size of cells and delivering a high amount of blood helps in getting more oxygen and perform the metabolic activity more and generate more energy. So including the exercise rapidly and continuously will help in increasing the muscle cells.

Describe the role of gravity in maintaining the atmospheric layer around Earth. I will mark as brainliest

Answers

Answer:

Hi so the answer is that Gravity pulls the gas molecules towards Earth's center. The pull of gravity is stronger closer to the center at sea level. Air is denser at sea level where the gravitational pull is greater. Gases at sea level are also compressed by the weight of the atmosphere above them.

Explanation:

I really hope i helped , pleaseeee give me brainliest , have a nice day and thank you in advance :))) .

When a genotype of a guinea pig is "Hh" (select all that are true)

One chromosome of the homologous pair has a sequence that results in hair and one chromosome has a sequence that results in no hair

One copy of the "H" allele on the homologous chromosome is enough to make the guinea pig have hair since both alleles are transcribed and translated

Only one of the chromosomes in the homologous pair carry the genetic sequence to make hair

Both chromosomes in the homologous pair carry the genetic sequence to make hair

Answers

Answer:

One chromosome of the homologous pair has a sequence that results in hair and one chromosome has a sequence that results in no hair

One copy of the "H" allele on the homologous chromosome is enough to make the guinea pig have hair since both alleles are transcribed and translated

Only one of the chromosomes in the homologous pair carry the genetic sequence to make hair

Explanation:

Hairy is dominant over hairless. If there was a hairless guinea pig here instead, we would know its genotype. It would be hh. Remember any time a dominant allele is present it is expressed in the phenotype, so if the phenotype is not the dominant one, we know the genotype must contain two recessive alleles.

These are the factors that is true, When a genotype of a guinea pig is "Hh"

• One chromosome of the homologous pair has a sequence that results in hair and one chromosome has a sequence that results in no hair

• One copy of the "H" allele on the homologous chromosome is enough to make the guinea pig have hair since both alleles are transcribed and translated

• Only one of the chromosomes in the homologous pair carry the genetic sequence to make hair

what was the worse hurricane and what year did it happen?

Answers

GALVESTON

It was the worst hurricane ever in the history

it is also known as great Strom of 1900

it killed more than 1900 people

Answer:

The Glaveston was the worst

Explanation:

...

DNA acts as a _____________ for living things
A. map

B. blueprint

Answers

Answer:

A. map

Explanation:

DNA acts as a map for living things.

What is a mutation?
A. A change that occurs in RNA only

B. A change that occurs in DNA only

C. A change that occurs in DNA or RNA

Answers

Answer:

C. A change that occurs in DNA or RNA

Explanation:

Mutation is a change that occurs in DNA or RNA. So, option (C) is the correct answer.

А
В
С
H
G
E
E
Which organelle is labeled A

Answers

i think its animal cell?

The reason for the length of day and night is the diurnal rotation because the sun cannot illuminate the whole earth at once when the earth is lit on one side it is day and when it is on the other side it is night

Answers

Answer:

Yes.

Explanation:

Yes, the sun cannot illuminate the whole earth at once when the earth is lit on one side it is day and when it is on the other side it is night. The earth rotates on its own axis which causes change of day and night. Due to this rotation, those areas which are in front of sun experience day while on the other hand, the shade part of the earth causes night at that part so we can say that  diurnal rotation is responsible for day and night.

Please help me with this

Answers

Answer:

bro ineed help to

Explanation:

Answer:

option 1 is the crt answer

Explanation:

B and j show more dna similarity as B is the direct ancestor of j

what is the device used to observe cells ?

Answers

Answer:

Microscope

Explanation:

A microscope is an instrument that can be used to observe small objects, such as cells. The image of an object is magnified through at least one lens in the microscope.

Question

What is the device used to observe cells?

Answer

Microscopes

What is Microscopes?

Microscope is an instrumet or device that can be used to observe small object , even cells or smal organisms.

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A scientist is comparing the sequences of related genes among three species. Two of the species have very similar sequences, while the sequence of the third species differs greatly from the others. T

Answers

Hi. The question you presented above is incomplete. This makes it impossible for this question to be answered. However, when searching for your question on the internet, I was able to find another question exactly like yours, which asked you to explain the evolutionary relationship between these three species. If that's the case for you, I hope the answer below will help you.

In a simplified way, we can infer that among the three species presented above, the third presented a faster evolution than the first two and this is what explains the difference between the gene sequences between the species. As the question presents, the three species have related genes, which indicates that they had a common ancestor, however the difference in the gene sequence of the third species shows that it evolved first, showing changes that cannot be noticed in the first two species that are evolving more slowly.

What ideas were changing in the scientific community at the time of Darwin's travels? How might those new ideas influenced Darwin?

Answers

Answer and Explanation:

At the time of Darwin's travels, the scientific community was beginning to abandon ideas linked to creationism to adopt more scientific and testable concepts, less linked to religiosity. Darwin was very influenced by these new concepts and decided to study a way to apply them to the biological diversity that planet earth presented. He wanted to explain this diversity through scientific data, obtained by experiments and logical reasoning, without the interference of creationist concepts and that would show how life on earth changes over the years and how species of living beings were created. This was one of the kicks that made him start his travels and his studies on biological evolution.

Gene expression establishes that genes will be turned on to build a protein.

A. TRUE

B. FALSE

Answers

The answer for this question is gonna be true

Answer:

A. TRUE

Explanation:

Gene expression establishes that genes will be turned on to build a protein.

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