Why is it essential for SARS-CoV2 RNA be translated on ribosomes before it can be replicated?

Answers

Answer 1

The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, suppresses host innate immune functions. By combining cryo-electron microscopy and biochemistry, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit in ribosomal complexes, including the 43S pre-initiation complex and the non-translating 80S ribosome. The protein inserts its C-terminal domain into the mRNA channel, where it interferes with mRNA binding. We observe translation inhibition in the presence of Nsp1 in an in vitro translation system and in human cells.


Related Questions

Lizard is a poikilothermic animal give reason please​

Answers

Answer:

Both reptiles and amphibians are poikilothermic, which means that they cannot regulate their own body temperatures internally 

Mark Brainliest please

Poikilothermic animals include types of vertebrate animals, specifically some fish, amphibians, and reptiles, as well as many invertebrate animals.

Reptiles are cold-blooded, or ectothermic, animals. This means that they cannot produce heat in their own bodies, and have to rely on their surroundings to keep warm. This is why most reptiles are found in hot or warm climates. Reptiles often bask in the sun to get warm.

Both reptiles and amphibians are poikilothermic, which means that they cannot regulate their own body temperatures internally as birds and mammals do.

6.Explain how animals in Vertebrata are classified into further subgroups.​

Answers

Answer:

Vertebrates are further classified according to several criteria like exoskeleton, respiratory organs, method of giving birth, number of chambers in heart, mode of living etc. They are further classified into classes Pisces, Amphibia, Reptilia, Aves and Mammals

Why are fungi more like animals than plants?

PLEASE HELP ME

Answers

Answer:

Hey mate.....

Explanation:

This is ur answer.....

However, unlike plants, fungi do not contain the green pigment chlorophyll and therefore are incapable of photosynthesis. That is, they cannot generate their own food carbohydrates by using energy from light. This makes them more like animals in terms of their food habits.

Hope it helps!

Brainliest pls!

Follow me! ;)

When cells are damaged, they release proteins called ____ ?

Answers

inflammatory chemical signals that evoke local vasodilation

Before you make a hypothesis—your best guess at a solution—what must you do?
Group of answer choices

Run an experiment

Make observations

Form a theory

Draw conclusions

Answers

Answer:

make observations .

Explanation:

Collect as many observations about a topic or problem as you can.

Evaluate these observations and look for possible causes of the problem.

Create a list of possible explanations that you might want to explore.

how does a cow drink water​

Answers

Answer:

cow will line up side by side and drink

Explanation:

They have to dip their mouth in without suck- ing air at the sides of their lips.

ep 3

1. Most students in Britain take the GCSE when ____________.

A. They are 11 years old

B. They are 16 years old

C. They finish grade 10

D. They begin grade 11

2. What is the first thing you’ll notice when you visit almost any school in Britain?

A. The school logo

B. The school gate

C. The school playground

D. The school uniform

3. What do most teenagers in Britain prefer to wear?

A. Trendy labels

B. Expensive uniforms

C. Fashionable hats

D. Economical trainers

4. The word ‘highlight’ in paragraph 2 is closest in meaning to __________ .

A. Confuse

B. Remark

C. Emphasise

D. Decrease

5. According to the passage, which of the following statements is NOT true?

A. Students in Britain can take 8 subjects at the GCSE.

B. Most British teenagers spend 2-3 hours watching TV after school.

C. Most 16-year-old students in Britain don’t like school uniforms.

D. Many British teenagers judge their friends by their shirts or trainers.

Answers

Answer:

1.c

2.d

3 .d

4.a

5.c

this is all I got

Use the drop-down menus to complete the hypothesis of the first group of researchers. During a drought, the decrease in rainfall will reduce the amount of vegetation that can grow and increase the occurrence of natural fires, so an elevation in Select… and a reduction in Select… should be found in the cores.

Answers

Answer:

Microscopic charcoal, Vegetation.

Explanation:

As the researchers conducting research in the Nile region identified that an increase in temperatures leads to an increase in droughts and reduction of natural vegetation and thereby the chances of the occurrence of natural fires.

Is there any plastid in mango seed?

Answers

there are no plastid in a mango seed because

is a hair tie a good example for the cytoplasm since a hair tie holds your hair together as the cytoplasm does to the rest of the organelles?

Answers

Answer:

I don't see why not, I mean, based on what I remember about my biology, I think that's a great example. :)

I love the model, but I guess if we go into further details cytoplasm holds a variety of organelles!

what's the cell wall of a onion made up of?

Answers

Answer:

Unlike animal cells (such as cheek cells) the cell wall of an onion and other plants are made up of cellulose, which protects the cell and maintains its shape.

Answer:

cell membrane,cytoplasm,nucleus and a large Vacuole.

Explanation:

An onion is a multicellular(consisting of many cells)plant organism.As in all plant cells,the cell of an onion peel consists of a cell wall.

What type of mutation is caused when a codon that corresponds to one of the twenty
amino acids specified by the genetic code is changed to a chain-terminating codon?

A nonsense mutation
B silent mutation
C chromosomal mutation
D missense mutation

Answers

D missence mutation
Is correct answer
D is the right answer. Missense mutation

The Channel Islands are a series of small islands off the California coast. Each island has a genetically distinct population of foxes. Compare the population of foxes on one of these islands to the population of foxes in the forests of mainland California. Which is more likely to be impacted by genetic drift? Which is more likely to be at Hardy-Weinberg equilibrium?

Answers

Answer:

The fox population on the Islands experiences genetic drift  whereas foxes in the forests has Hardy-Weinberg equilibrium.

Explanation:

The fox population on the Islands experiences genetic drift because there is no chance of introduction of different type of foxes in these Islands which experiences less variation in the population of already existing foxes. Genetic drift is the change that occur in the frequency of an existing gene allele in a population due to random sampling of organisms. Genetic drift may cause gene variants to disappear completely with the passage of time which leads to reduce genetic variation. The foxes that is located in the mainland forest experiences Hardy-Weinberg equilibrium.

Which of the following represents a mutualistic relationship?
1 point
Both organisms benefit
Both organisms do not benefit
One benefits and the other is unchanged
One benefits and the other is harmed

Answers

Answer: both organisms benefit

Explanation: mutualistic means that it is beneficial to both organisms involved

Hope that helped :)
Answer: Both organanisums benefit each other.
Explanation: Think of it as a business deal.If both the organisms give each other vital needs to survive,then we call that a mutual relationship. Example: rhizobium gives plant converted nitrogen and the plant give the bacteria the food water etc.

which of the following best describes the anthers of a flower?

Answers

Answer:

The anthers of a flower are the Male reproductive organ on the top of the stamen, which produce pollen.

What is the end product of glycolysis ?​

Answers

Answer:

pyruvate

Explanation:

Explanation:

The final product of glycolysis is pyruvate in aerobic settings and lactate in anaerobic conditions. Pyruvate enters the Krebs cycle for further energy production.

what does Cystic fibrosis do?
(please write in your own words)

Answers

Mark Brainliest please

Answer

CF causes thick mucus that clogs certain organs, such as the lungs, pancreas, and intestines. This may cause malnutrition, poor growth, frequent respiratory infections, breathing problems, and chronic lung disease.

The Symptoms of Cystic Fibrosis:

Chronic coughing (dry or coughing up mucus)
Recurring chest colds.
Wheezing or shortness of breath.
Frequent sinus infections.
Very salty-tasting skin.

Whats a hypothesis for “Which bait works better for a homemade fly trap?”

Answers

Answer:

If I use the correct bait, then I will have a successful homemade fly trap.

Explanation:

A hypothesis is always an "if, then" statement

In the 1950s the structure of DNA was discovered by using models and x-ray chromatography currently science has used advanced technology to completely map out the genes in a human's body. What would be the best advantage of using this information?

Answers

Answer:

Gene therapy to correct defective genes that cause diseases.

Explanation:

Gene therapy refers to the procedure that involves the introduction of nucleic acids (DNA or RNA) into the cells of an organism for the purpose of correcting abnormalities, such as a mutations or in other words to treat a genetic disease.Gene therapy entails bringing a normal and functional gene known as a trans-gene into a cell with altered gene. Another method can bring RNA capable of partially regulating or blocking the expression of an altered gene.The nucleic acids are introduced into the patient's cells by means of a viral vector or injected directly into the cells in the form of naked DNA.

pls mark brainliest

Why is the alpine tundra biome worth protecting WELL GIVE BRAINLIEST IF YOU CAN HLO ME

Answers

Struggled with this earlier but because of the high altitude only some animals can live there and thrive because of the lower oxygen levels

define and describe osmosis​

Answers

Answer:

Movement of a solvent (such as water) into a solution with a higher solvent concentration by means of a semi-permeable membrane (as from a live cell), which tends to equal solute concentrations in the membrane on both sides.

Explanation:

Osmosis, the spontaneous transition, distribution, or diffusion of water and other solvents over a semipermeable membrane. In 1877, a German physiologist, Wilhelm Pfeffer, researched the process, which is important in biology.

Osmosis is the passage of water down its concentration gradient, across a semi-permeable membrane. An everyday example is a plastic wrap in your kitchen: it allows air and water vapor to move across it, but no water or food. The membranes of cells are semi-permeable, too.

PLSSS HELLLPP- Which of the following measurements uses a derived unit? O volume O mass O length O time​

Answers

Answer:

Volume

Explanation:

volume=length ×length ×length

The metric system is the system used for the measurement. It measures the mass, length, weight, time, etc. The unit of volume is a derived unit. Thus, option A is correct.

What is a derived unit?

A derived unit is a unit used to measure and estimate the substance by using the basic or the fundamental metric unit system. It is based on units of the fundamental system.

The fundamental units include mass, temperature, time, luminous intensity, length,  electric current, and amount of substance. On the other hand, derived units result from a combination of base units.

A volume is a derived unit as it came from the fundamental unit of length as,

Volume = length × length × length

= cm × cm × cm

= cm³

Therefore, option A. volume is a derived unit.

Learn more about derived unit here:

https://brainly.com/question/13055377

#SPJ5

) An allosteric interaction between a ligand and a protein is one in which: (3 pts) A) binding of a molecule to a binding site affects binding of additional molecules to the same site. B) binding of a molecule to a binding site affects binding properties of another site on the protein. C) binding of the ligand to the protein is covalent. D) multiple molecules of the same ligand can bind to the same binding site. E) two different ligands can bind to the same binding site.

Answers

Answer:

B) binding of a molecule to a binding site affects the binding properties of another site on the protein.

Explanation:

In an allosteric interaction between a protein and a ligand, the ligand binds to a site in the protein. As a result, there is a change in the properties of other active sites on the protein. These active-site changes may or may not allow the protein to bind to other molecules. There is a change in the protein that affects the affinity of the active site for other molecules. The affinity on the active site increases if the protein binds to an activator and decreases if the protein binds to an inhibitor molecule.

Question 6 of 25
Which is an example of a vestigial structure?
A. Raccoon tail
B. Fish gills
C. Whale pelvis bone
D. Human arm
help:,)

Answers

the answer for your question is D

HELP!!!!!!!!!! Which of the following statements regarding membrane transport is false? I will mark brainliest!!!!!!!

Answers

Answer:

It is the 3rd one I believe

why us a spirogyra called a thallus ? which types of nutrition does it show ?why?​

Answers

Explanation:

a plant body that is not differentiated into stem and leaves and lacks true roots and a vascular system. hence spirogyra called a thallus.

Spirogyra is an example of Green algae , thus it prepare its own food by process of photosynthesis in presence of sunlight and chlorophyll.So, its nutrition type is Autorophic.

Help needed in biology…!

Answers

Answers:

viii) ATP

ix) To extract its chlorophyll

x) Amino Acids

xi) Aquatic submerged plants

xii) Rapid blood flow at high pressure

Hope this helps!

[I learned this in Bio this year so I know the answers]

Name three kinds of prokaryotic cells

Answers

Answer:

Euryarchaeota

Crenarchaeota

Nanoarchaeota

Answer:

lactobacillus acidophilus.

Cyanobacteria.

Archaea.

Both anaerobic and aerobic respiration use what to produce ATP and NADH?

Answers

Answer

glucozo

Explanation:

Which of the following could your family do to lower its carbon footprint?

Answers

Answer:

That's correct

Explanation:

Insulating homes lower footprint

Set the thermostat 2 degree warmer in winters could lower your family carbon footprint.

What is carbon foot print ?

A carbon footprint is the total amount of greenhouse gases (including carbon dioxide and methane) that are generated by our actions.

What does reducing carbon foot print mean?

Reducing your carbon footprint at home typically means consuming less energy.

To learn more about carbon footprint , here

https://brainly.com/question/24102961?referrer=searchResults

#SPJ3

Other Questions
Evaluate the expression 364 Given that x= 1/2 and y = 4 , evaluate 3xy + xy Which of the following could be the equation of the graph shown below? A Ribosome's primary function is to:A. Make an RNA copy of DNA.B. Translate mRNA into a protein.C. Make a DNA copy of RNA.D. Translate a protein into mRNA. How did Lincolns intentions in relation to slavery change from the beginning of the war to the end? PLEASE HELP NEED THIS ASAP PLEASE WILL MARK BRAINLIST TEN POINTS! PROMOSIE I WILL MARK BRAINLIST!Led by three young Black Minorca pullets, the hens made a determined effort to thwart Napoleon's wishes. Their method was to fly up to the rafters and there lay their eggs, which smashed to pieces on the floor. Napoleon acted swiftly and ruthlessly. He ordered the hens rations to be stopped, and decreed that any animal giving so much as a grain of corn to a hen should be punished by death. The dogs saw to it that these orders were carried out. For five days the hens held out, then they capitulated and went back to their nesting boxes. Nine hens had died in the meantime.Animal Farm,George OrwellWhich literary device does Orwell most use to support his purpose in writing in this passage?A. characters, to show that what happens on the farm is fiction.B. allegory, to show similarities between the farm and the Soviet Union.C. point of view, to show how the characters think about the murders.D. setting, to show that events in the Soviet Union may have been caused by the economy. A savings and loan association needs information concerning the checking account balances of its local customers. A random sample of 14 accounts was checked and yielded a mean balance of $664.14 and a standard deviation of $279.29. Find a 99% confidence interval for the true mean checking account balance for local customers. describe one displacement reaction that is useful and explain why it is useful Which statement expresses a shortcoming of conventionalism?a.)There can be no intercultural evaluation of what is good.b.)It is easy to determine what is right and wrong for everyone.c.)Most cultures do not differ on questions of morality.d.)Conventionalism delivers only intuitive results. Write a business letter to your branch manager informing him or her of the latest improvements you have done, as well as improvements you are planning to bring into effect soon, and how that would bring about great benefits to the business itself. InstructionsImagine that you're eating a 16-inch pepperoni pizza with your friends. It's so good that you've had four slices and washedthat down with a 16-ounce soda. Guess the nutritional value of your four-slice pizza and 16-ounce soda meal.Once you've made an educated guess, you're going to don your sleuthing hat and figure out the actual nutritional value.Go to your favorite pizza place's Web site or select a popular site that shows its nutritional values. Calculate how much ofyou ate and compare it to at least two similar meals, which you will also calculate. Your response must include: Dorsey Co. has expanded its operations by purchasing a parcel of land with a building on it from Bibb Co. for $89,000. The appraised value of the land is $26,000, and the appraised value of the building is $92,000.Required:a. Assuming that the building is to be used in Dorsey Co.s business activities, what cost should be recorded for the land?b. Indicate why, for income tax purposes, management of Dorsey Co. would want as little of the purchase price as possible allocated to land. (Select all that apply.) Land is a current asset. Land is not a depreciable asset. Land value will not reduce taxable income. Land is a depreciable asset. Land value reduces taxable income.c. Indicate why Dorsey Co. allocated the cost of assets acquired based on appraised values at the purchase date rather than on the original cost of the land and building to Bibb Co. Appraised values are to be used because they represent the historical asset value. Appraised values are to be used because they represent the book value. Appraised values are to be used because they represent the asset's current value.d. Assuming that the building is demolished at a cost of $11,000 so the land can be used for employee parking, what cost should Dorsey Co. record for the land? the numbers written in rectangles are the products of the numbers in connecting circle. Please solve it fast its urgent I have possess'd your grace of what I purpose:And by our holy Sabbath have I swornTo have the due and forfeit of my bond.If you deny it, let the danger lightUpon your charter and your city's freedom !You'll ask me, why I rather choose to haveA weight of carrion flesh than to receiveThree thousand ducats : I'll not answer that:But, say, it is my humour(1) Whom are these lines addressed to? What is the context in which theselines are spoken?(ii) What has Shylock sworn on oath ? If one angle of a triangle is 60and the ratio of other two is 1:3,find all the angles and the ratio of the sides. 2(x-4) +3(2-x) +2x +7 Find the measure of 2 E. Demonstrative Adjectives. Use the correct demonstrative adiective.1. (aqui) la clinica2. (alla) los antibioticos3. (alln las recetas4. (aqua) el paciente5. (alli) la enfermera6. (alla) la farmacia7. (aqul) el jarabe8. (alli) el mdico9. (alla) las radiografias10. (aqul) las pastillas what is the solution to this? Independent PracticeFind the number of solutions of the equation.0 = x2 + 2x + 9A.3B.2C.1D.0