AZT is a reverse transcriptase inhibitor. How does this drug prevent the replication of a retrovirus

Answers

Answer 1

Answer:

AZT is a thymidine analog

Explanation:

Azidothymidine (AZT) is an antiviral drug used for the treatment of the Human immunodeficiency virus infection (HIV/AIDS) by preventing the transmission of HIV from infected cells. AZT is capable of suppressing the activity of the enzyme reverse transcriptase of the retroviral HIV genome, which enables it to copy RNA into DNA. In infected cells, this double-stranded DNA is integrated into the host genome which is then instructed to produce identical HIV copies. AZT is a thymidine analog that is incorporated into DNA and thus interferes with DNA synthesis, thereby inhibiting cell proliferation.


Related Questions

why are g protein important for drug discovery?

Answers

Answer:

G protein - coupled  receptors(GPCRs)n belong to a large family of signaling proteins that  mediate cellular  reponses to most hormones ,metabolites,cytokines and neuotransmitters and therefore serve as fritful targets for DRUGS DISCOVERYS.

Explanation: histamine(HRH1),serotonin dopamine,opiod and adrenergic receptors.

I HOPE IT'S HELPS YOU TO UNDERSTAND

Which sentence about protist is accurate

Answers

Answer:

there are no sentences

Explanation:

Design a controlled experiment to test the effect of water temperature on goldfish. be sure to include your hypothesis, independent variable, dependent variable as well as experimental group and control group.

Answers

Answer:

In this experiment, indepedent variable will be temperature and dependent variable will be the respiratory rate of goldfish. Temperature affects the respiratory rate of goldfish, as it's respiratory rate decreases with decrease in temperature of water, the experiment is as follows:

Take two glass containers filled with water A and B and put one goldfish in each container.Measure the temperature of the water using a thermometer.Count mouth movement of both the fishes in certain time.Now put some ice in container B that will decrease the temperature of water and measure the temperature again.Now count the mouth movement of both the fishes for the same time it was counted earlier.

The result will be that respiratory rate of goldfish decreases with the decrease in temperature in container B in comparison to container A goldfish.

An experiment meant to determine the cause of an effect, the effect is the independent variable, while the cause is the dependent variable

A controlled experiment to test the effect of water temperature on goldfish is designed as follows:

The experimental group are: The gold fish in a glass Jar X filled with fresh water and with the lid left open (the treatment of temperature reduction is applied to the experimental group)

The control group are: A second gold fish (selected at random) of the same size, in another glass jar Y filled to the same level with fresh water collected from the same source of the first gold fish

Independent variable: The independent variable is the temperature of the water which will be varied by placing ice cube gradually into the glass jar B

Dependent variable: The number times the gold fish gulp air by rising to the surface, and or the number of time goldfish opens its mouth, which indicates that the goldfish is breathing

The hypothesis: The breath rate of goldfish decreases with decrease in temperature because the goldfish metabolic rate decreases and the water holds more dissolved air and therefore oxygen at a reduced temperature

The Experiment Design:

The experiment is conducted by measuring the initial temperature and breathing rate of both fishes

The temperature of the fresh water in jar X is decreased gradually by adding ice cubes and recording the temperature and breathing rate of the goldfish

A similar experiment from an online source (Maryland School improvement website) the following results where obtained

[tex]\begin{array}{|c|cc|} \underline {Breathing \ rate}&&\underline {Water \ Temperature } \\&&\\ (Dependent \ Variable)&&(Independent \ Variable)\ \\&&\\103&&78.8 ^{\circ}F\\78&&68^{\circ}F\\55&&57.2^{\circ}F\\28&&46.4^{\circ}F\\4&&35.6^{\circ}F\end{array}\right][/tex]

From the experiment, it can be seen that the in the experimental group dependent variable, which is the breathing rate of the goldfish reduces as the temperature which is the dependent variable is reduced

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The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane

Answers

Answer:

The question is incomplete, below is the completed question:

The main function of a cell membrane is to allow substances to enter and leave the cell. Which is a correct description of transport through a cell membrane ?

a. Diffusion, or passive transport, occurs when molecules diffuse from a lower concentration to a higher concentration.

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

c. The lipid bilayer opens up and allows the ions or molecules to enter the cell, then closes.

d. Active transport occurs when molecules diffuse from a higher concentration to a lower concentration.

Answer:

b. Facilitated transport occurs when proteins that extend through the cell membrane provide a channel through which certain substances can diffuse more rapidly than by passive diffusion.

Explanation:

Transport through cell membranes can be broadly classified as active transport or passive transport.

Active transport requires energy in the form of ATP for the transportation of substances across the cell membrane.

Option b correctly describes facilitated diffusion, which is a passive-mediated diffusion process, where channels in the cell membrane mainly composed of proteins called transmembrane integral proteins, allow for the movement of certain molecules (mostly polar/hydrophilic) molecules that will not otherwise be transported through simple diffusion because of the hydrophobic nature of the cell membrane.

The other options are wrong because:

a. diffusion or simple transport involves the movement of substances from regions of higher to a lower concentration not lower to higher as suggested here.

c. The lipid bi-layer does not allow ions or hydrophilic molecules because it is hydrophobic in nature, and it is not a channel, so it does not open and closes

d. In active transport, transfer of molecules is from regions of lower to higher concentration and not higher to lower concentration as suggested here.

Why are G proteins known as guanine nucleotide-binding protein?

Answers

Answer:

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. ... G proteins belong to the larger group of enzymes called GTPases.

What percentage of the nation’s demand for electricity could be produced in the future by wind energy?

Answers

Answer:

5-10%

hope this is helpful

What physical traits were favored in the peppered moth AFTER the Industrial Revolution?

Answers

Answer: Their skin color was dark which made the moths blend in. During the Industrial Revolution, the soot from factories caused the trees to become black. The light colored moths became easier to kill because they could not blend into their environment.

Explanation:

Circle
1
2
Circle the most reactive metal in each set.
1) Magnesium / Potassium
2) Aluminum / Gold
3) Cobalt / Cesium / Calcium
4) Iron / Titanium / Potassium
5) Francium / Lithium / Beryllium
لی

Answers

Answer:

Explanation:

1) potassium

2)Aluminium

3) Cesium

4) potassium

5) Beryllium

(06.03 LC) Which of the following is an example of how HIV can be transmitted from one person to another? Contact between infected blood and a mucus membrane Contact between infected saliva and an open wound Contact between infected blood and skin Contact between infected saliva and lining of mouth

Answers

Answer:

i believe the answer is contact between a infected blood and a mucus membrane

Explanation:

Use the following scenario to answer the next following question(s):

You and your friends go to the beach for vacation. You all walk down to the beach to go swimming. When you get there, you see the water is murky and green, and there are algae blooms floating on top.

Reference: Ref 6-3

If it is excess nutrients which are feeding the algae blooms and lowering the oxygen content in the water, that process is called:
A. nutrient cycling.
B. nitrification.
C. eutrophication.
D. hypoxia.

Answers

Answer:

eutrophication

Explanation:

Eutrophication refers to a situation in which the aquatic environment becomes excessively enriched with nutrients. This leads to algal blooms in aquatic habitats such as lakes. These nutrients come from Fertilisers used in farming, which find their way into water bodies through run-off thereby increasing nutrient levels.

Excess nutrients causes phytoplankton to grow and reproduce at an alarming rate resulting in algal blooms. This bloom disrupts the balance in the ecosystem leading to many problems.

The algae may end up using all the oxygen in the water, causing oxygen shortage for aquatic life. Some of the algae may die, their decay may lead to further oxygen depletion. As oxygen is depleted, aquatic organisms may also begin to die.

____________ a regulatory protein that may bind DNA to inhibit transcription. ____________ a DNA sequence that binds a regulatory protein. ____________a DNA sequence that binds RNA polymerase and regulates transcription. ____________a compound that interacts with another protein or compound to form an active repressor ____________a compound that induces or activates transcription, such as lactose.a. Repressorb. Operator c. Promoterd. Corepressore. Inducer

Answers

Answer:

A repressor is a regulatory protein that may bind DNA to inhibit transcription. An operator is a DNA sequence that binds a regulatory protein. A promoter is a DNA sequence that binds RNA polymerase and regulates transcription. A corepressor is a compound that interacts with another protein or compound to form an active repressor. An inducer is a compound that induces or activates transcription, such as lactose.

Explanation:

Repressor proteins bind to DNA and RNA to suppress target gene expression. A DNA repressor blocks transcription by inhibiting the attachment of RNA polymerase to the promoter sequence, while an RNA repressor bind to the mRNA to block translation of the protein. An operator is a DNA sequence required for the attachment of transcription factors. The genes that are transcribed by the binding of a transcription factor to an operator sequence are collectively referred to as an operon. Operons are generally found in prokaryotes but they also can be found in some eukaryotes including Caenorhabditis elegans and Drosophila melanogaster. An inducer is a molecule that activates gene transcription either by binding to repressors/corepressors (thereby inactivating their functions) or by binding activators. For example, the allolactose act as an inducer of the lac operon.

Which location is least likely to experience a volcanic eruption? Α. an island hot spot, such as the island of Hawaii B. Hamilton County on the plains of central Texas с. a convergent boundary, as in the Ring of Fire D a volcanic island arc, such as the Aleutian Arc in Alaska

Answers

Answer:

i think that the answer is B. Hamilton County on the plains of central Texas i took the test

Explanation:

Hamilton County on the plains of central Texas is least likely to experience a volcanic eruption. Therefore, option (B) is correct.

What are volcanoes?

Molten rock and gases stored under the surface erupt through a volcano, generating a hill or mountain.

Active, inactive, or extinct volcanoes. Active volcanoes are likely to erupt again. Dormant volcanoes may erupt again. Extinct volcanoes won't erupt.Magma collects inside active volcanoes. The magma chamber's pressure forces it through rock channels and onto the planet's surface.

Volcanic eruptions can be violent or slow-moving. Volcanoes erupt through vents on the sides or a primary entrance at the top. The volcano's morphology depends on eruption rate and magma chemistry. Land and sea volcanoes exist. As lava cools and hardens, underwater volcanoes build mountains and ranges. When volcanoes rise above the ocean, they create islands.

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In the image, the arrow Is pointing to a celestial object. Which attribute disqualifies the object from being a planet?
A. It appears to have no moons.
B. It is spherical in shape.
C. Its neighborhood is not clear.
D. It has horizontal bands on its surface.

Answers

The correct answer is C. Its neighborhood is not clear.

Explanation:

One of the key features of a planet is that it clears its neighborhood; this means the planet gravitational force is strong enough that there are no other celestial bodies on its orbit or next to it except by its moons or satellites. This does not occur in the image presented because there are smaller celestial bodies near to the main or bigger celestial body. This likely occurs if the celestial body is not big enough to clear its neighborhood, and therefore it is not a planet.

PLEASE ANSWER QUICK!The Greek roots of the word prokaryote mean “before nucleus.” Describe the way that DNA is organized in prokaryotic cells without the help of a nucleus. How does this approach differ from the way that eukaryotic cells organizes their DNA

Answers

Answer:

Prokaryotic cells' DNA are located in the cytoplasm of the cell rather than in the nucleus, like in eukaryotic cells. DNA aids in protein synthesis and determines functions of the cell in cells, regardless of being within the membrane of a nucleus or not.

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I hope this helps a little.

The word prokaryote in Greek means before kernel (nucleus). Unlike the eukaryotic cells, the nuclear material is located in the cytoplasm of the cell in a nucleoid.

What are the characteristics of prokaryotic cells?

The prokaryotic cells are the primitive karyons that are defined by the lack of the true nucleus and organelles. Unlike the eukaryotes, the organelles lack the membrane that covers them but has a tough cell wall.

The prokaryotes include archaea and bacteria which are unicellular and microscopic organisms that are simple and have their genetic material organized into nucleoids in the center of the cell. They have the ability to live in harsh conditions.

Therefore, the eukaryotes and prokaryotes differ in the arrangement of the genetic material.

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A mutation that hides the effect of another mutation at a site that is distinct from the site of the original mutation, but with in the same gene. This mutation is best described as a

Answers

Answer:

The correct answer is intragenic suppressor mutation.

Explanation:

A suppressor mutation partially or completely converses the effects of a different mutation. A suppressor mutation is of two kinds, that is, an intragenic suppressor and an intergenic suppressor. An intragenic suppressor converses the influence of a mutation at a distinct site in a similar gene.  

On the other hand, an intergenic suppressor converses the influence of a mutation at a distinct locus of the gene. It is the intragenic suppressor mutation, which takes place in a similar gene where the occurrence of the first mutation had taken place. Therefore, the mutation, which hides the influence of another mutation at a location, which is different from the location of the original mutation, but taking place in a similar gene can be illustrated as the intragenic suppressor mutation.  

A.While the traits studied in Exercise 1 were hypothetical genetic traits, what type of genetic traits do you think are important to study and predict

Answers

Answer:

Genetic disturbances harmful to the organism are genetic characteristics that must be studied and predicted.

Explanation:

Genetic disorders that harm an organism such as sickle cell anemia, hemophilia, Turner syndrome, among others, are important to be studied and predicted, because it will provide better maintenance of that organism. Allowing people who inherit these characteristics to have more efficient treatments and a better life, since the prediction of these characteristics allows the family to establish better adapapitativo methods, that will make the life of this individual easier and with more quality.

ABO blood type is examined in a Taiwanese population, and allele frequencies are determined. In the population,
f (IA) = 0.30,
f(IB) = 0.15, and
f (i) = 0.55.
What are the frequencies of the various genotypes and various phenotypes in this population? Assume Hardy-Weinberg equilibrium.

Answers

Answer and Explanation:

Due to technical problems, you will find the answer and explanation in the attached file.

Which type of nuclear power reactor is used in only 1 percent of all power plants?

Answers

Answer:

Breeder reactors

Explanation:

The type of nuclear power reactor that is used in only 1 percent of all power plants would be Breeder reactors.

Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?
A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes

Answers

Answer:

C) proteins with gain-of-function mutations

Explanation:

Gain-of-function mutations: In biology, the term "gain-of-function mutation" is described as one of the different types of mutation in which the altered or changed "gene product" consists of an entirely new pattern or molecular function associated with gene expression. However, the "gene-of-function mutations" are being always considered as "Semidominant or Dominant".

In the question above, the correct answer is option C.

When the body cells are hypotonic to the blood plasma, water will move from intracellular fluid to extracellular fluid.
A. True
B. False

Answers

Answer:

True

Explanation:

Every interaction with the outside world is because of A) epithelial tissue B) connective tissue C) nervous tissue D) muscular tissue

Answers

Answer:

A cutaneous membrane is a multi-layered membrane composed of epithelial and connective tissues. The apical surface of this membrane exposed to the external environment and is covered with dead, keratinized cells that help protect the body from desiccation and pathogens....

identify the components ( parts) of DNA

Answers

Answer:

Phosphorus group, a sugar(like deoxyribose or ribose), and a nitrogenous base

Is the talc renewable?

Answers

Answer:

no.its nonrenewable.

talc is nonrenewable.

thanks.

What complications might arise from genetic screens targeting an organ that differentiates late in development?

Answers

Answer:

No sign of testicular development in boys and breast development in girls.

Explanation:

Complications like no sign of testicular development in boys and breast development in girls occurs if an organ develop very late. There are many causes of this type of complications such as long term illness, eating improper food and disorder of sexual development. Sometime these complications  also occurs due to genetically. These complications should be treated well with medication and use of nutritious food. These medicines increases the performance of sex hormones in order to initiate puberty.

QUICKLY! The chemical reaction equation of photosyntesis is shown here: What information is not given in this equation. It does not show if the reaction is reversible. It does not show the reactants needed for the reaction. It does not show that photosynthesis consists of many separate steps. It does not show the number of molecules required to produce glucose.

Answers

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

Photosynthesis is a unique process carried out by the cells of autotrophic organisms. It is the process whereby they synthesize their own food in form of sugars (glucose) in the presence of sunlight. Ideally, the photosynthetic process makes use of carbon dioxide (C02) and water (H20) in the presence of light energy (from sun) to produce glucose sugar (C6H12O6) and oxygen (02). The general photosynthetic equation is as follows:

6CO2 + 6H20 + light → C6H12O6 + 6O2

However, the process is not as simple as portrayed as it involves many separate steps that collectively forms the photosynthetic product (glucose). Photosynthesis occurs in two major stages namely: light stage and light independent stage, which in turn consists of series of reactions that forms the products.

Therefore, the equation attached to this question describes photosynthesis but It does not show that photosynthesis consists of many separate steps.

Answer:

C: It does not show that photosynthesis consists of many separate steps.

Explanation:

assuming hardy weinberg equilibrium what is the probability that sarah who is phenotypically normal with no family history and tom

Answers

Answer:

The probability of having a disorder is 50 %.

Explanation:

The offspring has that genetic disorder if the Sarah who is phenotypically normal with no family history and tom has a genetic disorder so there is 50 percent chance that the children of Sarah and tom has that genetic disorder. if the disorder linked with Y chromosome of male so this disorder is present in the sons but if the disorder linked with X chromosome of male so this disorder is present in the daughters.

What makes up the backbone of a DNA molecule? nucleic acids RNA molecules sugars and phosphates ribose and deoxyribose

Answers

Base, sugar and phosphate and deoxyribose make up a nucleotide on a DNA molecule

Answer:

sugars and phosphates

Explanation:

gradpoint

The diagram represents a food pyramid. The concentration of the pesticide DDT in individual
organisms at level D is higher than the concentration in individuals at level A because DDT is
A. produced by organisms at level C ingested by
those in level D
B. passed through levels A, B, and C to organisms
at level D.
C. excreted by organisms at level A as a toxic
waste.
D. synthesized by organisms at level D.

Answers

Answer:

The answer is "Choice b".

Explanation:

In the given question diagram is missing. so first, we define the diagram after that we explain why the above given choice is correct.  

In the attached file the food pyramid can be a divide into the level, in which the D pesticides use the "dichloro-diphenyl-trichloroethane ", which concentration is higher than its entities from the level of A because DDT is transferred with species at level D by levels A, B, and C, that's why the choice "b" is correct.  

RNA polymerase is an enzyme that copies (1 point)
o DNA into DNA.
O RNA into mRNA
O mRNA into tRNA.
DNA into RNA

Answers

Answer:Copies DNA into RNA

Explanation:

A decrease in muscular activity or damage to neurons that attach to skeletal muscle can lead to a reduction in the size of muscle called

Answers

Answer:

The correct answer is atrophy

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What two regions became tributary states of the mongols A triangle has vertices at (-4,-6),(3,3),(7,2). Rounded to two decimal places, which of the following is closest aporoximation of the perimeter of the triangle Someone help me plzz Drag each tile to the correct box. Arrange the events in the order in which they happened in the world how many people die every day Help please on this question. Id appreciate it if you answered. Find the length of AB -5+2(10b-2)=31 need help thanks! Find the equation of a parabola that has a vertex (3,5) and passes through the point (1,13).Oy= -27 - 3)' +5Oy=2(x + 3) - 5Oy=2(0 - 3)' + 5Oy= -3(2 3) + 5PLEASE HELP ME!! Function g can be thought of as a scaled version of f(x)=|x| what is the equation for g(x)? Suppose that there are two types of tickets to a show: advance and same-day. The combined cost of one advance ticket and one same-day ticket is $65 . For one performance, 25 advance tickets and 35 same-day tickets were sold. 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Train X, traveling at a constant rate, completed the 100-mile trip in 5 hours; Train Y, traveling at a constant rate, completed the 100-mile trip in 3 hours. How many miles had Train X traveled when it met Train Y?(A) 37.5(B) 40.0(C) 60.0(D) 62.5(E) 77.5 young apple-tree, which, planted by birds or cows, had shot up amid the rocks and open woods there, and had now much fruit on it, uninjured by the frosts, when all cultivated apples were gathered. It was a rank wild growth, with many green leaves on it still, and made an impression of thorniness. The fruit was hard and green, but looked as if it would be palatable in the winter. Some was dangling on the twigs, but more half-buried in the wet leaves under the tree, or rolled far down the hill amid the rocks. The owner knows nothing of it. The day was not observed when it first blossomed, nor when it first bore fruit, unless by the chickadee. There was no dancing on the green beneath it in its honor, and now there is no hand to pluck its fruit,which is only gnawed by squirrels, as I perceive. It has done double duty,not only borne this crop, but each twig has grown a foot into the air. And this is such fruit! Bigger than many berries, we must admit, and carried home will be sound and palatable next spring. What care I for other apples so long as I can get these? 2 When I go by this shrub thus late and hardy, and see its dangling fruit, I respect the tree, and I am grateful for Natures bounty, even though I cannot eat it. Here on this rugged and woody hillside has grown an apple-tree, not planted by man, no relic of a former orchard, but a natural growth, like the pines and oaks. Most fruits which we prize and use depend entirely on our care. Corn and grain, potatoes, peaches, melons, etc., depend altogether on our planting; but the apple emulates mans independence and enterprise. It is not simply carried, as I have said, but, like him, to some extent, it has migrated to this New World, and is even, here and there, making its way amid the aboriginal trees; just as the ox and dog and horse sometimes run wild and maintain themselves. 3 Even the sourest and crabbedest apple, growing in the most unfavorable position, suggests such thoughts as these, it is so noble a fruit. Excerpt from "Wild Apples" by Henry David Thoreau. In the public domain. I Hear America Singing by Walt Whitman I hear America singing, the varied carols I hear, Those of mechanics, each one singing his as it should be blithe and strong, The carpenter singing his as he measures his plank or beam, The mason singing his as he makes ready for work, or leaves off work, 5The boatman singing what belongs to him in his boat, the deckhand singing on the steamboat deck, The shoemaker singing as he sits on his bench, the hatter singing as he stands, The wood-cutters song, the ploughboys on his way in the morning, or at noon intermission or at sundown, The delicious singing of the mother, or of the young wife at work, or of the girl sewing or washing, Each singing what belongs to him or her and to none else, 10The day what belongs to the dayat night the party of young fellows, robust, friendly, Singing with open mouths their strong melodious songs. "I Hear America Singing" by Walt Whitman, from Leaves of Grass. In the public domain. Question 1 Which sentence BEST states the authors point of view regarding people who are ambitious? A It was a rank wild growth, with many green leaves on it still, and made an impression of thorniness. B Some was dangling on the twigs, but more half-buried in the wet leaves under the tree, or rolled far down the hill amid the rocks. C Most fruits which we prize and use depend entirely on our care. D It is not simply carried, as I have said, but, like him, to some extent, it has migrated to this New World, and is even, here and there, making its way amid the aboriginal trees. Help me please please please please help please, got a little lost in everything g The electronic structure of which ONE of the following species cannot be adequately described by a single Lewis formula? (In other words, the electronic structure of which one can only be described by drawing two or more resonance structures?) A) C2H4 B) SO3 2 C) SO3 D) C3H8 E) HCN Will is 10 years old and preparing for a spelling contest. He is starting to memorize the spelling of the word antidisestablishmentarianism. He realizes that he can group the letters into anti, dis, establish, and so forth. This process is called ____.Will is 10 years old and preparing for a spelling contest. He is starting to memorize the spelling of the word antidisestablishmentarianism. He realizes that he can group the letters into anti, dis, establish, and so forth. This process is called ____.