The most common Class II variant is the F508del variant, which is missing the 508th amino acid in the protein but has an otherwise normal sequence. Loss of this amino acid leads to misfolding of the protein, and the misfolded protein is not properly transported to the membrane. Based on this information, how many nucleotides are deleted in the CFTR allele encoding this variant?

Answers

Answer 1

Answer:

The correct answer is - 3 (two codons of 507th that are U, C, and the first nucleotide of 508th codon U).

Explanation:

Each amino acid is coded by a three-nucleotide base long codon. So in the case of the F508del variant, there is a deletion of three nucleotides that is encoded for phenylalanine amino acid.

In this isoleucine is encoded by 507th codon that is AUG and 508th codon is UUU codes for Isoleucine.

In this case, two codons of 507th are U, C, and the first nucleotide of 508th codon U. So overall three nucleotides are deleted in the F508del variant..


Related Questions

Describe the similarities and differences between the cheek cell wet mount and dental plaque wet mount.

Answers

Answer:

Cells from the cheek are a type of epithelial cell, similar to skin. ... They can be seen faintly even at 40x (scanning power), but the most dramatic images are at 400x where the nucleus is clearly visible as a dark spot in the center of the cell.

Explanation:

Los microondas tienen una frecuencia mayor a las ondas de radio. verdadero o falso,justifique

Answers

Los microondas tienen una frecuencia mayor a las ondas de radio.Verdadero o Falso.

Verdadero.

→ Porque, los microondas con/y las radiofrecuencias son radiaciones electromagnéticas de mayor frecuencia.

SALUDOS!

MiraculousAlejandra

The immunoglobulin light chain does not have a D segment. In humans, there are two different possible light chain proteins, termed kappa and lambda. Assume that there are 35 V segments and 5 J segments in the human kappa light chain region, and there are 30 V segments and 4 J segments in the human lambda light chain region. How many possible light chain genes can be created from these different segments, simply due to combinatorial diversity

Answers

Answer:

295  

Explanation:

Antibodies (also known as immunoglobulins) are immune system-related proteins that circulate in the bloodstream in order to recognize pathogenic harmful substances (antigens) and neutralize them. An antibody consists of two immunoglobulin heavy chains and two immunoglobulin light chains. There are two types of immunoglobulin light chains: 1-the kappa (κ) light chain, which is encoded by the immunoglobulin κ locus; and 2-the lambda (λ) light chain, which is encoded by the immunoglobulin λ locus. The immunoglobulin light chain is a multidomain protein composed of two domains: 1- the N-terminal variable (V) domain and 2-the C-terminal constant (C) domain. V(D)J recombination is a type of somatic rearrangement process by which T and B cells can assemble different gene segments, which are referred to as variable (V), diversity (D) and joining (J) gene segments. In the question above the number of possible genomic recombination events between immunoglobulin gene segments can be calculated as >> (5 x 35) + (4 x 30) = 295.

Indicate whether each statement is true or false: 1. Compliance is the tendency for blood vessel volume to increase as blood pressure decreases. True 2. Blood vessels with a large compliance exhibit a small increase in volume when the pressure increases a small amount. True 3. Venous compliance is approximately 24X greater than arterial compliance, so as venous pressure increases the volume of veins greatly increases. True

Answers

Answer:

1. False

2. False

3. True

Explanation:

1. Compliance is the capacity of a container to increase in size to allow it hold more content. Blood vessel, arteries and veins expand (increase in volume) to be able to accommodate a surge in blood flow, which is as a result of an increase in pressure of the blood from the heart pumping of the blood

Therefore, compliance in the tendency for blood vessel volume to increase as the blood pressure increases not decrease

The statement is false

2. A large compliance is indicative of being highly sensitive to changes in pressure

Compliance, C = ΔV/ΔP

From the above equation, a blood vessel with a large compliance, exhibit a large increase in volume when the increase in pressure is small

Therefore, the statement 'Blood vessels with a large compliance exhibit a small increase in volume when pressure increases a small amount; is false

3. The compliance of the vein ranges from 10 to 20 times (30 times in some literature) greater than arteries. A factor which can be affected by the vascular smooth muscle contraction or relaxation

Therefore, the statement, 'venous compliance is approximately 24 times larger than arterial compliance, so as venous pressure increases the volume of veins greatly increases' is true

2. What kind of plants contain tubular structures that are used to conduct water from the soil through the roots?
non-vascular plants
seedless plants
seed plants
vascular plants

Answers

Answer:

Vascular plants

Explanation:

I took the quiz

Which of the following is not a natural disaster ?

1 . Tsunami
2. Earthquake
3. Terrorism
4. Hurricane

Answers

Answer:

terrorism

Explanation:

everyhthing else is natural because hurricanres come from wind and tide overflow tsunamis are caused by earth quakes and earthquakes are natural

The one that follows that is not a natural disaster is the terrorism that is present in Option 3, as the terrorism is done by man while the natural disasters are caused by nature, such as the hurricane and earthquake.

What role does a natural disaster play in the ecosystem?

Natural disasters are phenomena caused by nature, such as cyclones, earthquakes, and tsunamis, and they cause significant damage, which may be indirectly caused by man as man causes global warming, climate change, and so on. The terrorism is man-made or artificial, as certain people are involved and harm other people or the country.

Hence, the one that follows that is not a natural disaster is the terrorism that is present in Option 3, as the terrorism is done by man while the natural disasters are caused by nature, such as the hurricane and earthquake.

Learn more about the natural disaster here.

https://brainly.com/question/13154257

#SPJ2

How do make a sperm cell go in to a woman

Answers

During sex, sperm cells travel through the vagina to the uterus and fallopian tubes. In the fallopian tube, the sperm meets the egg that was released from the ovary during ovulation.

Which characteristic of a dog is inherited?


Barking

Doing tricks

Walking on a leash

Whining for food

Answers

Answer:

Barking is inherited characteristic of dog.

Explanation:

They inherit that from their ancestors.

Barking
The other is learn

Help .....plz help....​

Answers

Answer:

2. sedimentation (decantation follows sedimentation)

3. immiscible (water and oil never mix with each other)

4. size

5. evaporation (condensation chills the mixture where evaporation heats the mixture )

pls mark it as brainliest

Answer:

pls mark it as brainliest

sedimentation

immiscible

evaporation

pls mark it as brainliest

A solid form of precipitation is _____________.

Answers

Answer:

precipitate

Explanation:

the examples would be; evaporation, snow, hail, or clouds.

Macronutrients is the most readily available for energy production

Answers

Answer:

The correct answer is - true.

Explanation:

All the macronutrients carbohydrates, fats, and protein all three produce energy. Carbohydrates are the most preferred source of energy for the human body as it is the macronutrient that your system most requires.

The human body easily breaks down most carbohydrates and provides a significant amount of energy. The energy-providing process is called cellular respiration starts with glucose as a substrate. Glucose is the simplest carbohydrate.

Why do producers (plants) have an opportunity to thrive after wildfires?

Answers

Answer:

Thick bark.  

Trees in fire-prone areas develop thicker bark, in part, because thick bark does not catch fire or burn easily. It also protects the inside of the trunk

Fire-induced sprouts.  

This fire-survival strategy allows for the complete destruction of above-ground growth

what happen to Potato chips when put into salt water?​

Answers

Answer: the potato chip becomes a substance that is soft and very floppy

All human impacts on the environment, such as the depletion of natural resources, are significantly worsened by __________. air and water pollution climate change human population growth agricultural practices

Answers

Answer:

overpopulation

Explanation:

this along with the others listed have triggered climate change and soil erosion

Most physical characteristics are inherited. Scientists have discovered several genes that contribute to human fatness, particularly genes that regulate the production of specific ____________ , such as ____________ , which stimulates hunger, and ____________ , which reduces hunger.

Answers

Answer:

hormones; ghrelin; leptin.

Explanation:

Genetics can be defined as the scientific study of hereditary in living organisms such as humans, animals and plants.

Heredity refers to the transfer of traits (specific physical characteristics) from the parent of a living organism to her offspring through sexual reproduction or asexual production. Some examples of hereditary traits are dimples, tongue rolling, baldness, handedness, freckles, curly hair, color blindness, height, etc.

A gene can be defined as the complete set of hereditary instructions that is typically found in the deoxyribonucleic acid (DNA).

Over the years, scientists have discovered several genes that are known to contribute to human fatness (body weight), especially genes that are saddled with the responsibility of regulating the production of specific hormones, such as ghrelin, which stimulates hunger, and leptin, which reduces hunger.

A biologist discovered a new animal. Upon studying its embryonic development, she observed radial cleavage with the blastopore developing into an anus. This animal was categorized as a parazoan. pseudocoelomate. deuterostome. protostome. radiata.

Answers

Answer:

The correct answer is ''deuterostome''.

Explanation:

Deuterostomes are a superphylum of animals in which the anus is formed in or near the blastopore area in the developing embryo, and the mouth is secondarily formed elsewhere. The oral apparatus that these adult animals enjoy does not come from the embryo's blastopore. Instead it is a new formation. They enter the Bilateria classification, where species that enjoy bilateral symmetry are incorporated. In deuterostomes, the primary phases of division occur in parallel to the axis between the tips. That is, the segmentation they have is radial when the embryo is in state 1 with four cells.

if you look away from this sentence and focus your eyes on a distant object, the eye muscles _______ to focus images on the retinas

Answers

If you look away from this sentence and focus your eyes on a distant object, the eye muscles relax to focus images on the retinas.

As a group, you and three other students must make a presentation on an animal. Which option is the best example of your group coming to a consensus on the
presentation topic?


The group cannot agree on what animal to choose so your teacher chooses your presentation topic.

Each member gets a vote and the animal with the most votes will be the presentation topic.

A group member is selected as the team leader and the team leader chooses the presentation topic.

The group writes options on slips of paper, puts them in a hat, and the paper that is selected will be the presentation topic

Answers

Each member gets a vote and the animal with the most votes will be the presentation topic, is the best example of your group coming to a consensus on the presentation topic.

what are the different types of presentation ?

Presentations should be always unique as  the information we are trying to present.

An informative presentation is always educational, concise, and only specific points are mentioned.

The main aim of an informative presentation is to share information with  others.

An Instructive Presentations teaches to the audience on a specific topic, but it goes beyond sharing facts.

Persuasive Presentations is to sell something or persuade the audience to take actions. It present  an issue  and explain their solution using data.

Motivational Presentations is an inspiring presentations, aim to generate interest in an audience’s approval.

Decision-making Presentations is to shares a problem, their solution and their outcomes can help speed along the process.

For more details regarding presentation, visit:

https://brainly.com/question/12257858

#SPJ2

Gene expression can be summarized as
DNA is translated to mRNA that is then transcribed to
make a protein.
O
DNA is transcribed to mRNA that is then translated to
make a protein.
Protein is translated to mRNA that is then transcribed
to make DNA.
mRNA is transcribed to DNA that is then translated to
make a protein.

Answers

Answer:

3 one

Explanation:


What happens when the density of a medium increases?

Answers

A substance that is more dense per volume has more mass per volume. Usually, larger molecules have more mass. If a material is more dense because its molecules are larger, it will transmit sound slower.

Please help;
Given the range of current speeds shown on the graph above, would deposition ever be possible for clay (0.001 mm) or silt (0.01mm) particles?
Answer yes or no and explain your answer.

Answers

Answer:

Yes.

Explanation:

Yes, deposition can be possible for clay (0.001 mm) and silt (0.01mm) particles when the agent that carry its load is absent in that region such as wind. Wind is the agent that moves clay and silt particles with it so if there is high wind in a specific region, no deposition will occur while on the other hand, those areas where wind is not present, deposition will definitely occurs so we can say that deposition depends on the presence and absence of wind.

Which purpose is the main function of the light-dependent reactions of photosynthesis?

Answers

Answer:

The overall purpose of the light-dependent reactions is to convert light energy into chemical energy. This chemical energy will be used by the Calvin cycle to fuel the assembly of sugar molecules. The light-dependent reactions begin in a grouping of pigment molecules and proteins called a photosystem.

The light-dependent reactions convert light energy into chemical energy. The goal of the light-dependent reactions of photosynthesis is to collect energy from the sun and break down water molecules to produce ATP and NADPH. These two energy-storing molecules are then used in the light-independent reactions.

Do you think that organisms of the same order will share a stronger evolutionary relationship than organisms that share only the same phylum? Explain your reasoning using the results of your investigation.

Answers

Answer:

In taxonomic, the organism is classified based on some similarities. ... But the organism with the same order should have the same phylum and class too since order is located below the phylum. That means the organism with the same order should have more similarities than the organism with the same phylum.

Taxonomical classifications are done for organisms including plants, animals, microorganisms etc. It classifies, defines and scientifically names organisms.

According to the taxonomical classification the organisms are classified based on similarities and in order of the taxonomy, the organism should have the same phylum and class.

In taxonomy, the phylum is above the order in level and the phylum will have fewer similarities compared to the organism in order or class.

The organism of the same order will have a strong evolutionary relationship as compared to the organism with the same phylum.

To learn more about taxonomical classification follow the link:

https://brainly.com/question/1918761

Locate each of the following general areas of your body as listed in the background by pointing to areas on your body in reference to body orientation terms. Become familiar with these terms so you can eventually recall their meanings without referring to the background.

a. Anterior
b. Caudal
c. Cephalic
d. Deep

Answers

Answer:

a. Anterior: Refers to the front of the body, which comprises the face and abdomen.

b. Caudal: Refers to the lower structures of the body, starting from the waist towards the foot.

c. Cephalic: Refers to the entire head region.

d. Deep: Refers to the inner core regions of the body, such as the bones within the muscle, the organs, among other internal structures.

Explanation:

The regions of the body presented above are very important for all health professionals, as it facilitates the study and understanding of the human body and the structures that make it up. In addition, the memorization of these terms allows health professionals to talk clearly about the injuries that patients have and the best way to treat them.

Listt any four general characteristics of pisces.​

Answers

Dishonesty, caring, passionate for what they do and kind to those around them.
Me though I wouldn’t know I’m a Aries

what is the waterfalls ​

Answers

Answer:

waterfall is a falling of a river or other body of water over a steep Rocky ledge. Shows interruption in water flow

Part 1 of 1 -
Question 9 of 10
10 Points
When DNA is copied, sometimes there are mistakes. Approximately how often does this
happen?
O A. There aren't any mistakes.
OB. 1 in a billion bases.
OC. 1 in a million bases.
OD. 1 in a trillion bases.
Reset Selection

Answers

Answer:

D. 1 in a trillion bases

Explanation:

A mutagen agent can change the genetic information of organisms increasing mutations over the natural level. Mutagens cause changes in the bases, and pairing bases, that compose DNI strands.

A mistake in the process of DNI copy during cell division might cause genetic changes in daughter cells. Defects DNI replication might be inherited if it occurs in germinal cells. But it can also cause many significant epigenetic changes.

Many of these changes can be detected on time by enzymes such as DNI polymerase. This enzyme can correct these mistakes or at least some of them, moving from 3´to 5´direction, and eliminating the mistakes.

The highly effective replication system, together with the action of enzymes, makes it rare to occur a mistake in DNI replication. Generally speaking, the mistaken rates in DNI replication are very low, meaning that only one in a trillion times occurs a mistaken DNI copy.

What is produced during the replacement reaction of Ba(NO3)2 and Na2SO4?

2BaNa + 2NO3SO4
2NaNO3 + BaSO4
NaNO3 + BaSO4
BaNa2 + (NO3)2SO4

Answers

Answer:

2NaNO3 + BaSO4

Explanation:

Answer:

2NaNO3 + BaSO4

Explanation:

Hydrocarbons are burned to produce water and carbon dioxide. Propane (C3H8) is a homologous series alkane that belongs to the hydrocarbon family. As a result, when propane is burned, three molecules of carbon dioxide and four molecules of water are produced.

Because there is an overabundance of oxygen, carbon dioxide is created when butane is completely burned.

how do the decisons that we make each day influence how efficiently our body operates

Answers

Answer:

Our decisions have direct impact on the operations or actions of our body.

Explanation:

The decisions that we make each day greatly influence our body and efficiently our body operates because the activities we do in daily life put pressure on our body system. If our decisions force us to do hard work so it makes our body more stronger and healthier as compared to those decisions which requires no hard work so our body is not strong enough and our body can't operates efficiently.

what is gestation period?​

Answers

Gestation is the period of development during the carrying of an embryo or fetus inside viviparous animals.[1] It is typical for mammals, but also occurs for some non-mammals. Mammals during pregnancy can have one or more gestations at the same time, for example in a multiple birth.
The time interval of a gestation is called the gestation period. In human obstetrics, gestational age refers to the fertilization age plus two weeks. This is approximately the duration since the woman's last menstrual period (LMP) began.

Answer:

gestation period is the period of development during the carrying of the embryo or fetus inside viviparous animals

Other Questions
An investment advisor has a client base composed of high net worth individuals. In her personal portfolio, the advisor has an investment in Torex, a company that has developed software to speed up internet browsing. She has thoroughly researched Torex and believes the company is financially strong yet currently significantly undervalued. According to the GARP Code of Conduct, the investment advisor may: Why did totalitarian governments control culture, such as books and films? to ensure that all citizens had access to the arts to support writers, directors, and other artists to prevent culture from playing any role in society to make sure that all culture followed state ideology Given: UR ST R, T right angles Prove: RSU TUS What you will get:25 pts Brainliest what is the sum of -2and-18 Find the missing side length in the image below He Had His Dreamby Paul Laurence DunbarHe had his dream, and all through life,Worked up to it through toil and strife.Afloat foreer before his eyes,It colored for him all his skies:The stormcloud darkAbove his bark,The calm and listless vault of blueTook on its hopeful hue,It tinctured every passing beamHe had his dream.He labored hard and failed at last,His sails too weak to bear the blast,The raging tempests tore awayAnd sent his beating bark astray.But what cared heFor wind or sea!He said, The tempest will be short,My bark will come to port.He saw through every cloud a gleamHe had his dream.19Select the correct answer from the drop-down menu.How does the poet develop theme?The poet develops the theme by . The word radiation is used to describe particles or waves that are emitted by an object (known as a source) and carry energy. Name two types of radiation other than nuclear radiation. For each type, name one source of that type of radiation. Find the missing side length image below Find the amount of force required to move an object of 1200 kg at a velocity of 54 km/hr? Cash Flow Activity 1. Sold stock investments for cash. 2. Received cash payments from customers. 3. Paid cash for wages and salaries. 4. Purchased inventories with cash. 5. Paid cash dividends. 6. Issued common stock for cash. 7. Received cash interest on a note. 8. Paid cash interest on outstanding notes. 9. Received cash from sale of land. 10. Paid cash for property taxes on building. 15x + 45 = 15 (3 + x) always never one solution how do I do it 1. You ( not be ) ....... any use to me unless you learn to tybe 2. If I ( have ) ..... enought money , I will buy a new skateboard 3.She will be angry if you ( not , tell ) ...... the truth4.If they take their medicine , they (feel) ..... better5 . We ( not , get) .... good marks if we don't learn hard 6.If he ( not , go) .... back now , he will be late7.They ( not / let)..... you in if you come late 8.If you ( not/go) .... away , I'll send for a policeman Future solution for air pollution in new zealand hello help pleaseExpress [tex] \frac{3}{5} [/tex]of a right angle triangle to radian measure and can some anybody help me by looking one old question from my profile help please Gii phng trnh lng gic c bn sinx=cos2x Match each leadership skill to its advantage.communicationgoal settingchange managementteam buildinghelps the group adapt to new developmentshelps individuals work togetherwhile supporting each otherhelps individuals measure their progresshelps the leader clarify team understandings In 1990, the average math SAT score for students at one school was 498. Five years later, a teacher wants to perform a hypothesis test to determine whether the average SAT score of students at the school has changed from the 1990 mean of 498.The hypotheses are shown below. Identify the Type II error.H0:=498Ha:498A. Fail to reject the claim that the average math SAT score is 498 when in fact it is not 498.B. Reject the claim that the average math SAT score is 498 when in fact it is not 498.C. Reject the claim that the average math SAT score is 498 when in fact it is 498.D. Fail to reject the claim that the average math SAT score is 498 when in fact it is 498. explain 2 ways in which water and ion balance are maintained? name the organs and any hormones involved Given that the temperature of a body is 527K determine the value in degree C Regina has 3 bags of marbles. There are 25 marbles in each bag. She wants to put an equal number of marbles into 5 bags. Which expression would show how many marbles can go in each bag?