Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?
A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes

Answer:

False

Explanation:

The correct answer is false because Reabsorption of water and other filtered solutes like vitamins, sodium e.t.c. take place in the proximal convoluted tubules.

Reabsorption is when water and solutes in the PCT are removed and moved back into the blood and it's a process that take place through bulk transport.

The solutes and water are transported from the PCT to the interstitium and then move into peri-tubular capillaries and reabsorption in PCT is isosmotic i.e solutes have the same osmotic pressure.

Answer:Oxygen

Explanation:

Answer:

a . Fish need 10 ml of water purifier to survive.

Explanation:

Fish need 10 ml of water purifier to survive because the data of 10 ml and 20 ml purifier is the same so it is recommended to use 10 ml purifier. First the data was same but by recording next week data, it shows slightly increase in the value of tank 2 while in the last week, both has the same value so we can concluded that by using 10 ml purifier is enough for the fish to survive.

Answer:

Its B/More purifier is needed to keep heated water clean.

Explanation:

Answer:

3.page is this that answer

Explanation:

a.1,2,3,4

The correct sequence for western blotting is: C. 1,3,2,4

Blotting can be defined as an analytical technique that is designed for the analysis of biological macromolecules such as:

For western blotting, the correct sequence of analyzing biological macromolecules such as proteins is:

1. The denaturation of protein through the use of sodium dodecyl sulfate (SDS) and by boiling.

2. The performance of polyacrylamide gel electrophoresis (PAGE).

2.The transfer of proteins to the nitrocellulose membrane.

4. Lastly, the incubation of the nitrocellulose membrane to subsequently form primary antibodies and secondary antibodies.

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Answer:

Diploid Genotype - Genotype of Gametes

RR - R

rr - r

Rr - R, r

Explanation:

According to Gregor Mendel in his law of Segregation, he stated that the alleles of a gene gets separated into gametes during gamete formation (meiosis). This occurs in such a way that only one allele of the two possible alleles that make up the genotype of a diploid organism is found in the gamete.

Meiosis is a cell division that reduces the chromosomal number of the daughter cells. Hence, a diploid organism (2n) will undergo meiosis to produce haploid (n) daughter cells (gametes). An organism with a diploid genotype RR will produce gametes which have only genotype R. The same applies to organism with genotype rr. Only gametes with genotype, r, will be produced.

However, in a heterozygous genotype like Rr, the different alleles will separate into gametes in an equal proportion i.e. gametes with genotypes R and r will be produced in a ratio 1:1.

Answer:

The answer is A.

Explanation:

The best fossil evidence that suggests Neandertals' ability to produce a language like modern humans comes from the hyoid bone.

This bone is located in the neck between the chin and the thyroid, which is also named "tongue bone" or "language bone".

So the correct answer is A.

I hope this answer helps.

Answer:

Glomerular Hydrostatic pressure .

Explanation:

The basic function of the kidney is the formation of urine for elimination through the urinary excretory system. Two different processes determine this formation: the filtration of fluid through the glomerular capillaries into Bowman's space and the modification of the volume and composition of the glomerular filtrate in the renal tubules.  The fluid passes from the glomerular capillaries to Bowman's capsule due to the existence of a pressure gradient between these two areas. This process is favored by two structural characteristics that make renal corpuscles particularly effective filtration membranes: glomerular capillaries have a much higher number of pores than other capillaries, and the efferent arteriole has a smaller diameter than the afferent arteriole, causing greater resistance to outflow of blood flow from the glomerulus and increasing glomerular hydrostatic pressure. Increased glomerular hydrostatic pressure (due to increased blood flow through the glomerulus) increases filtration, while increases in Bowman's hydrostatic pressure or urinary space (which remains constant, unless there is disease at that level, usually due to fibrosis) and plasma P. oncotic (determined by proteins, which tend to "drag" plasma into the glomerulus) decrease filtering. Resulting in a filtering pressure of 10 mmHg.

Answer:

I'll say its B ) Question

Explanation:

because when your proving something with evidence then you start asking questions (or still have questions) makes it seem like you don't really know.

Answer:

D. Oxygen

Explanation:

Oxygen is the most abundant element in the bodies of living things. For example, oxygen is about 65% of the human body.

Oxygen in the body is mostly in the form of water, since the bodies of living things need water to create energy needed every day.

Answer:

No its not

Explanation:

Hey there!

Conjoined fish is a very rare occurrence that does not happen often.

Hope this helps :)

Answer: zap70, ITAM.

Explanation:

An antigen is any substance that is capable of stimulating an immune response by activating lymphocytes, which are the body’s infection-fighting white blood cells. Examples of antigens could be proteins that are part of bacteria or viruses or components of serum and red blood cells from other individuals, all of them are foreign antigens originated outside the body. However, there can also be autoantigens (which are self-antigens), originated within the body. In normal conditions, the body is able to distinguish self from nonself. And the antigens that represent a danger induces an immune response by stimulating the lymphocytes to produce antibody or to attack the antigen directly. This is called an antigenic stimulation of the immune system.

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein that is part of the T cell receptor, thereby it plays a critical role in T-cell signaling. When the TCR (receptor of T cells) is activated by the presentation of the specific antigen through the MHC, a protein called Lck acts to phosphorylate the intracellular CD3 chains and the ζ chains of the TCR complex, allowing the binding of the cytoplasmic tyrosine kinase, ZAP-70. Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as an anchor site for several other proteins. The tyrosine phosphorylation cascade initiated by the Lck culminates in the intracellular mobilization of calcium ion (Ca2+) and the activation of important signaling cascades within the lymphocytes. These include the Ras-MEK-ERK pathway, which is based on activating certain transcription factors such as NFAT, NFκB and AP-1. These transcription factors regulate the production of of certain gene products, most notably cytokines such as interleukin-2 that promote the long-term proliferation and differentiation of activated lymphocytes.

The ITAM motifs (immunoreceptor tyrosine-based activation motif) are sequences of four amino acids present in the intracellular tails of certain proteins that serve as receptors within the immune system. Thus, some receptors such as the TCR have ITAM sequences that, when activated, trigger an intracellular reaction based on consecutive phosphorylations.  Kinases are recruited for this purpose.

So, ZAP-70 is a protein tyrosine kinase with a role in T-cell receptor signal transduction. During T-cell activation, ZAP-70 binds to ITAM and becomes tyrosine phosphorylated. The binding of ZAP-70 to the phosphorylated ITAM is able to activate its kinase activity, and relieves the inhibition of the transcription factor which regulates genes that are involved in the immune reaction.

Answer:

Outside of the body, nares, vestibule, nasal cavity, choanae, nasopharynx, oropharynx, laryngopharynx, and larynx.

Explanation:

During inspiration, the air enters through the nares in the nose.  From here, it goes up passing through the vestibule, the nasal cavity, and the choanae to start descending through the pharynx. The pharynx has three parts: the nasopharynx, which is in contact with the nose; the oropharynx that is in contact with the mouth; and the laryngopharynx, which is in contact with the larynx and esophagus. Between the oropharynx and laryngopharynx is the epiglottis, this is cartilage that prevents food from going to the lungs when we swallow food. After passing through the pharynx, the air flows through the larynx. From here, the air goes to the trachea, the bronchi, which enters the lungs giving the bronchioles, and these divide giving the alveolus, which is the place where the exchange of Oxygen and Carbon dioxide occurs.              

Placing the respiratory structures in the correct order :

Outside of  Body --> nares --> vestibule --> nasal cavity --> choanae --> nasopharynx --> oropharynx -->  laryngopharynx --> larynx -- > inside of body

During respiration the air enters from outside of the body into the body through the nares down to the vestibule, the nasal cavity which will descend down through to the pharynx which is further divided into three ( 3 ) parts which are; nasopharynx,  oropharynx, and laryngopharynx. The epiglottis is located between oropharynx and laryngopharynx.

Hence we can conclude that Placing the respiratory structures in the correct order ; Outside of  Body --> nares --> vestibule --> nasal cavity --> choanae --> nasopharynx --> oropharynx -->  laryngopharynx --> larynx

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Answer:

C

Explanation:

Zlrozdzidkzzkxhkcgkxtkckgcgkckzxtixkgx

Answer:

E) A pH less than 7

Explanation:

if a solution has a higher concentration of hydronium ions than pure water , it has a pH lower than 7

Answer: e

Explanation:

I did the test

Answer:

2,500x

Explanation:

am doing the review rn

Answer:

1,000x

Explanation:

i got yall

Answer:

yes they very much are!!!!!!!!!

Answer is given below

Explanation:

If you have an antimicrobial agent specific for each of the targets listed below

Answer:

2nm

Explanation:

(10KM/S)/(5HZ) = 2nm

Answer:

Air go from one place to another due to difference in temperature of land and sea.

Explanation:

Air go as a result of wind from one place to another. Air moves from land to sea is called land breeze and from sea to land is known as sea breeze. This will occur when there is difference in temperature between sea and land. Sea breeze occurs at afternoon while land breeze occurs at night till morning. Warm air produces low pressure and cold air produces high pressure so when warm air rises, cold air takes its place and this cycle continues.

Extinction of the Ordovician: This extinction was responsible for the disappearance of about 60-70% of the species of oceanic life, This is because in that period most of the life on Earth was in the ocean. This extinction is believed to have been caused by an intense glacial period, although short that froze most of the planet's water. It is believed that the species most affected were sponges, algae, jawless fish, molluscs and cephalopods.

Devonian Extinction: Responsible for the disappearance of about 75% of marine species. This extinction was caused by the depletion of oxygen in the ocean, making life impossible for all aerobic marine organisms. This depletion of oxygen was caused mainly by the variation in the level of the ocean and climatic changes that may have been caused by asteroids.

Permian Extinction: Responsible for the death of 95% of life on earth. This extinction is known as the "mother of all extinctions" due to its destructive character, which devastated life on land and in the ocean. It is believed that this extinction was caused by volcanic activities triggered by the impact of asteroids. Almost all living species on earth were affected, such as insects, trilobites, sharks, boneless fish, reptiles, among others.

Extinction of the Triassic: It is not known exactly what caused this extinction, but it is estimated that it had the power to decimate 70-80% of terrestrial life, mainly arcosaurs and amphibians. The most accepted theory today is that the extinction was caused by recurrent volcanic activities that influenced huge volumes of carbon dioxide in the atmosphere, generating intense heating.

Cretaceous extinction: It was caused by the impact of an asteroid with the earth. The impact had the power to exterminate 75% of terrestrial life. This is the most well-known extinction, since it was responsible for decimating dinosaurs, however, some animals survived this impact, such as most marine species, frogs, birds, reptile and mammals.

Explanation:

Hey, there!!

According to what i have learned, the biggest mystery about virus is; It acts like both living and non- living beings.

living characters includes :

non- living characters:

Hope it helps...

Answer:

5' ATTGCAGGTCCGTTT 3'

Explanation:

Complimentary strands of DNA run anti-parallel to each other, the ends facing in opposite directions.

The complimentary base pairs for DNA are:

A=T and C=G and when finding the complimentary strand these pairs are only paired with each other.

Answer:

Reversible reaction

Explanation:

If the elements of the product combine together in a chemical reaction, this reaction is called reversible reaction because the reaction moves in backward  or reverse direction. For example, if acid i. e. HCl combine with base i. e. NaOH which are the reactants, it produces two products salt (NaCl) and water (H2O). If salt (NaCl) and water (H2O) combine again with each other, it produces acid i. e. HCl and base i. e. NaOH, such type of reaction is called reversible reaction.

Answer:

Yes, glucose dissolves in water.

Explanation:

Hello,

In this case, we can state that glucose is largely soluble in water due to the fact that it has five of polar hydroxyl groups which can interact with the hydrogen atoms in the water throughout the hydrogen bonds. Such hydrogen bond is known as an intermolecular force that forms a special type of dipole-dipole attraction when a hydrogen atom bonded to a strongly electronegative atom (like the oxygen in the hydroxyl groups) exists in the vicinity of another electronegative atom with a lone pair of electrons, therefore they occur among molecules.

Answer:

b) the plastic bag was permeable to iodine

the plastic bag was selectively permeable

the iodine moved into the plastic bag.

the plastic bag was permeable to cornstarch.

Explanation:

The experimental set up represented the concept of osmosis.That is  the movement of water  molecules from the region of higher  water potential to region of lower water potential through a semipermeable membrane(a  cell membrane which only allows water and certain molecules to pass through,but restrain other molecules through its pores.

Generally potassium iodine test is the standard test for starch.

Therefore, in the question,water moves iodine molecules as iodine solution(from high water potential) to move across the paper bag(semi permeable membrane) to the reach the corn solution.(low water potential,high solute potential).This turns the starch in the corn solution  blue-black/purple.

If the solution in the plastic bag turned dark purple:

To test for the presence of starch in a solution, iodine solution is used. This gives a blue-black coloration which occurred due to the formation of a starch-iodine complex.

From the above experiment, the plastic bag which contains the corn starch solution, separates the solution from water containing 10 drops of iodine.

The turning of the solution, inside the plastic bag, into blue black signifies the formation of starch-iodine complex between the cornstarch solution the iodine water.

The reaction was able to occur because the plastic bag, which is selectively permeable to iodine, allowed the movement of iodine from the beaker of water into it. This is called diffusion.

Therefore, if the solution in the plastic bag turned dark purple it means that the plastic bag which is semi permeable allowed the movement of iodine into it.

Learn more here:

https://brainly.com/question/24529068

Answer:

Corn

Explanation: