Cystic fibrosis is most common in individuals of Northern European descent, affecting 1 in 3200 newborns. Assuming that these alleles are at Hardy-Weinberg equilibrium, what is the frequency of the disease-causing CFTR alleles in this population

Answers

Answer 1

Answer:

0.0177

Explanation:

Cystic fibrosis is an autosomal recessive disease, thereby an individual must have both copies of the CFTR mutant alleles to have this disease. The Hardy-Weinberg equilibrium states that p² + 2pq + q² = 1, where p² represents the frequency of the homo-zygous dominant genotype (normal phenotype), q² represents the frequency of the homo-zygous recessive genotype (cystic fibrosis phenotype), and 2pq represents the frequency of the heterozygous genotype (individuals that carry one copy of the CFTR mutant allele). Moreover, under Hardy-Weinberg equilibrium, the sum of the dominant 'p' allele frequency and the recessive 'q' allele frequency is equal to 1. In this case, we can observe that the frequency of the homo-zygous recessive condition for cystic fibrosis (q²) is 1/3200. In consequence, the frequency of the recessive allele for cystic fibrosis can be calculated as follows:

1/3200 = q² (have two CFTR mutant alleles) >>  

q = √ (1/3200) = 1/56.57 >>

- Frequency of the CFTR allele q = 1/56.57 = 0.0177  

- Frequency of the dominant 'normal' allele p = 1 - q = 1 - 0.0177 = 0.9823


Related Questions

In pulsus paradoxus, even if the pulse cannot be palpated, it can still be heard by using a BP cuff and stethoscope.

a. True
b. False

Answers

Answer:

False.

Explanation:

Pulse can't be heard by using a BP cuff and stethoscope because these devices are used to measure the heartbeat and blood pressure of the body. Digital monitors display both blood pressure and heart rate, but you can determine the pulse by checking your pulse by using hand while on the other hand, heartbeats can easily be heard using a good stethoscope so we can say that pulse can't be heard through BP cuff and stethoscope.

Read each description below regarding the the CNS control of the ANS.

a. It's the integrating centers for reflexes controlling heart rate and blood pressure.
b. It activates the fight-or-flight response.
c. It's the integrating center for thermoregulaton.
d. Sexual thoughts or images can increase blood flow to the genitals.
e. It's the major control center of the ANS.

1. Cerebral Cortex
2. Hypothalamus
3. Brainstem
4. Spinal Cord

Answers

(1)The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex.

(2)The hypothalamus is a small region of the brain. It's located at the base of the brain, near the pituitary gland. While it's very small, the hypothalamus plays a crucial role in many important functions, including: releasing hormones. regulating body temperature.

(3) The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata Ten pairs of cranial nerves come from the brainstem.

(4)The spinal cord is a long, fragile tubelike structure that begins at the end of the brain stem and continues down almost to the bottom of the spine. The spinal cord consists of bundles of nerve axons forming pathways that carry incoming and outgoing messages between the brain and the rest of the body.

Cell Parts and Their Jobs
1. Label the parts of these two cells in the spaces provided. (pg. 175)
I
Mitochondrion
cell membrane
enroplasmic reticulcm
nucleus
nucleolus
Go
cytoplasm
0
MO

Answers

Answer:

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Explanation:

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Select all the correct answers.
Which two of these characteristics does an organism with bilateral symmetry possess?

Answers

Answer:

symmetrical in many ways across a central axis" and  "presence of a head".

Explanation:

Bilateral symmetry is a characteristic that many organisms has at which if we divide the body using an imaginary line, we will see two mirror images. Two characteristics that an organism with bilateral symmetry possess are symmetrical in many ways across a central axis (known as well as the sagittal plane), and presence of a head that is at the middle of the central axis. The great majority of organisms posses bilateral symmetry, including the humans.

Which phrase best describes a savana biome

Answers

Answer:

A biome that is dry most of the time long tall dried out grass. The savanna is home to many large land mammals, including elephants, giraffes, zebras, rhinoceroses, buffalo, lions, leopards, and cheetahs. Other animals include baboons, crocodiles, antelopes, meerkats, ants, termites, kangaroos, ostriches, and snakes.

Explanation:

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A savanna biome is a biome that’s practically like a dessert but it has grass and trees so it’s a dried out biome

what is the total number of bones in the skeleton system​

Answers

Answer:

Bones provide the structure for our bodies. The adult human skeleton is made up of 206 bones.

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In algae and plants, photosynthesis happens in the
vacuoles.
mitochondria.
chloroplasts.
chromosomes.

Answers

Answer:

chloroplast........................

Answer:

chloroplasts

Explanation:

they contain chlorophyll, a necessary element for photosynthesis

What similarities and differences do you see with our human species?

Answers

Answer:

similarities: body differences:attitude

Explanation:

everyone has body with similar properties such as hand,leg and eye.while attitude they have good and bad depends on the education they get.

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Identify the number of electrons each of the following atoms needs to gain or lose to have a stable outer electron configuration: Sodium(Na), Sulfur(S), Strontium(Sr)

Answers

Answer:

Sodium: +8

Sulfur: +2

Strontium: -2

1. A week after returning from a backpacking trip, four teenagers developed nausea and severe diarrhea. All had consumed untreated water from a stream which doctors concluded was infested with the organism, Giardia. Think about the symbiotic relationships that you studied in this unit. What type of relationship exists between the teens and the organism?

2. As humans burn fossil fuels for energy, the percent of carbon stored in fossils is reduced while the carbon in the atmosphere is increased. If green plants are also being removed, how might the carbon cycle and greenhouse effect be influenced?

3. How are decomposers critical to the carbon cycle?

Answers

Answer:

Explanation:

1) The relationship that exists between the teens and the organism (Giardia) is Parasitism. Because in such symbiotic relationship one species (the parasite-Giardia) benefits while the other species (the host- the teens) is harmed.

2) Plants remove Carbon dioxide (a major green house gas) from atmosphere during photosynthesis. But, if plants are also being removed with increase in use of fossil fuels, the CO2 that escapes the fossil fuels will remain in the atmosphere for longer as there are not enough plants to "suck" them back into a stored form of Carbon. Carbon Dioxide increases green hourse effect thus green house effect will increase and earth's temperature might rise due to this.

3) Without decomposers we would not be able to continue the carbon cycle because we could not release the stored carbon from plants and animals into the atmosphere. Decomposers break down dead material from organism and release carbon dioxide into the atmosphere, where it's available to plants for photosynthesis. Without them, we could not recycle nutrients or carbons in our ecosystem and thus, they are critical for the carbon cycle.

The protein calcineurin binds to the protein calmodulin with an association rate of 8.9 × 103 M-1s-1 and an overall dissociation constant, Kd, of 10 nM. The dissociation rate kd is:_____. Please explain step by step.
A. 8.9 × 10^3 M-1s-1
B. 8.9 × 10^2 s-1
C. 1.1 × 10-10 s-1
D. 8.9 × 10-5 s-1

Answers

Answer:

D

Explanation:

From the information given:

Association rate [tex]K_a[/tex] = [tex]8.9 \times 10^3 M^{-1}s^{-1}[/tex]

dissociation constant [tex]K_D[/tex] = 10 nM

dissociation rate [tex]K_d[/tex] = ???

Using the following relation from equilibrium dissociation constant to determine the dissociation rate, we have:

[tex]K_D =\dfrac{ K_d}{K_a}[/tex]

[tex]K_d = K_D \times K_a[/tex]

[tex]K_d =(10*10^{-9} \ M) \times (8.9*10^3 \ M^{-1}{s^{-1})[/tex]

[tex]\mathbf{K_d =8.9*10^{-5} \ {s^{-1}}}[/tex]

Discuss how important you think it is to protect ecosystems from human-induced change, such as changes in habitat or introduction of invasive species. Should natural conditions be preserved at all costs, should human needs always prevail, or is the answer somewhere in between? Discuss the negative consequences of taking an approach that you disagree with.

Answers

Answer:

Humans impact the physical environment in many ways: overpopulation, pollution, burning fossil fuels, and deforestation. Changes like these have triggered climate change, soil erosion, poor air quality, and undrinkable water.  ecosystems are vital for human welfare and survival, as they provide us with essential products and benefits.

Over 90% of our food comes from terrestrial ecosystems, which also provide energy, building materials, clothes, medicines, fresh and clean water, and clean air. Protecting wildlife and preserving it for future generations also means that the animals we love don't become a distant memory. And we can maintain a healthy and functional ecosystem.

Question 4 Multiple Choice Worth 2 points)
In the diagram below, what is the property of the wave indicated by the letter A?
- amplitude
- crest
-frequency
-trough

Answers

Answer:

- trough.

Explanation:

The Trough is the lowest wave section, the minimum wave part. It's the other way around from crest.A wave or alternating signal minimal point.

A long, narrow depression, waves or ridges between them.

A low point in a corporate cycle or on a graph.

An extended area of relatively low pressure, often in conjunction with the front.

Which question cannot be answered through making measurements?

A. Should the government invest in technologies that can reduce the rate of global warming?
B. How much carbon dioxide is released into the atmosphere when a square mile of tropical rain forest burns?
C. What is the relationship between carbon dioxide emissions and average global temperature?
D. Which human activities contribute to global warming?​

Answers

Answer:

A and D

Explanation:

Warfarin acts by inhibiting the activity of the VKORC1 protein, which helps to produce functional clotting factors. There is a variant in the VKORC1 gene that lowers the dose of warfarin required for treatment, and individuals with this variant have increased risk of bleeding when they are treated with warfarin. This variant is found 1639 base pairs upstream of the translational start site. This variant likely:______.
a. decreases the activity of the VKORC1 protein.b. increases the activity of the VKORC1 protein.c. decreases expression of the VKORC1 gene.d. increases expression of the VKORC1 gene.

Answers

Answer:

The correct answer - c. decreases expression of the VKORC1 gene.

Explanation:

Mutation of Guanine nucleotide into Adenosine is the reason for this particular type of mutation. This mutation expresses the less expression of the VKORC1 protein.

The mutation results in a decrease in the affinity of the binding site of the transcription factor which causes less expression. Since the VKORC1 protein is less in the body so Warfarin doses are decreased  

Thus, the correct answer is - decreases expression of the VKORC1 gene.

vai trò, cấu tại, thuộc tính của hợp chất thứ cấp

Answers

Hợp chất thứ cấp là các chất không có chức năng trực tiếp trong các quá trình đồng hóa, hô hấp, vận chuyển, tăng cường và phát triển thực vật. Chức năng chủ yếu của các hợp chất thứ cấp là bảo vệ thực vật chống lại các tác nhân gây bệnh và động vật ăn cỏ. Nhiều chất thứ cấp có hoạt tính sinh học mạnh được dùng làm chất diệt côn trùng, nấm, dược chất. Hợp chất thứ cấp được phân làm ba nhóm chính ở thực vật: Các terpen, các hợp chất phenolic và các hợp chất chứa Nitrogen.

A muscle that is stimulated so frequently that the relaxation phase is eliminated is said to exhibit _______. Question 13 options: tetanus recruitment treppe wave summation

Answers

Answer:

tetanus

Explanation:

Tetanus causes a strong tonic contraction in skeletal muscles. This triggers a series of intermittent, progressive, and extremely painful muscle spasms. Tetanus is presented by patients who have stimulated a muscle too often, without allowing a moment of rest.

identifying technological advancement

Answers

Answer:

It occurs to create innovation in the existing technology.

Explanation:

A technological advancement is an attempt to develop current materials, devices, products or processes by further understanding of science.  technological advancement provides innovations of existing technology or formation of new technology in order to better the life style and make easier our work. If the technological advancement did not occur, we are unable to increase efficiency of various instruments and machines.

Explain the importance of studying cytology ​

Answers

Answer:

Each cell in the body and its components - tissues and organs - is a functional and structural entity. As a result, examining cytology can aid in the differentiation of normal and afflicted cells, as well as the identification of the disease's etiology at the cellular level.

OAmalOHopeO

Toluene crosses pure lipid bilayers many hundreds of times faster than a related compound, phenylalanine. Suggest two different properties of these molecules that would account for this difference.

Answers

Answer:

The lipid bilayer is hydrophobic that is hydrophobic and it can easily cross the lipid bilayer.

Toulene is a hydrophobic and neutral molecule compound so it can easily pass through the bilayer. It is an aromatic compound with a methane group attached to the benzene ring. It is smaller in comparison to Phenylalanine.

Phenylalanine-- It is an amino acid with a benzene ring attached to it. This amino acid is less hydrophobic than the aliphatic amino acids. Because of its less hydrophobic nature, it travels slowly compared to Toluene. It is also larger and has amino and carboxyl groups attached to it. On the other hand, Phenylalanine is a polar compound which has -COOH and -NH2 group. which prevents its delay in its transport across the lipid bilayer.



What does a single colony of a pathogenic microbe represent?

Answers:
A clone
A species
A serotype
All answers are correct
No answers are correct
Question 9

Answers

Answer:

clone

Explanation:

D - Telophase
C - Anaphase
A - Prophase
B - Metaphase
th
Choose the correct description for each phase of mitosis.

Answers

Answer:

A-B-C-D

Explanation:

PROPHASE; 1. chromosomes become thicker

2. nuclear membrane disintegrates

3. centrosome divide to form centrioles

4. centrioles move to the opposite polls of the cell

METAPHASE; 1. chromosomes get arranged at the equator

2. centrioles produce spindle fibre that attach to the middle of the chromosomes

ANAPHASE; 1. shortest stage of mitosis

2. spindles will pull apart each chromosomes to form chromatids

TELLOPHASE; 1.  each chromatid moves to opposite polls of the cell

2. nuclear membrane appears around both of them

3. the centrioles sill stop producing spindles

4. centrosomes will then form again

cytokinesis then divides by the cleavage furrow to form the two daughter cells

For the following three cultures, using any resource find out if they are obligate aerobes, facultative anaerobe, or obligate anaerobe- o Escherichia coli o Micrococcus luteus o Clostridium sporogenes

Answers

Answer:

Escherichia coli - Facultative anaerobe

Micrococcus luteus - Obligate aerobe

Clostridium sporogenes - Obligate anaerobe

Explanation:

In simple terms, obligate aerobes are organisms that require oxygen to grow and metabolize molecules such as fats and sugars to produce energy. Many animals fall under this category. Other examples are Mycobacterium tuberculosis and Micrococcus luteus.

Facultative anaerobes are organisms (usually bacteria) that can grow both in the presence and absence of oxygen. The most example of this are the Escherichia coli.

Obligate anaerobes are organisms (usually microorganisms) that cannot survive when exposed to normal atmospheric concentration of oxygen. Examples are Clostridium sporogenes and Clostridium botulinum.

1.) Citrus Red Mites can disperse to other locations by ______.

Choose the best answer.

a. crawling and roping.

b. using their wings to fly.

c. egg expulsion shot into other plants.

d. being carried by other insects.




2.) Mark all correct answers.

The mouth parts of insects are important for these reasons.



They can help us identify the insects

They tell us how they feed on a plant

What show the sort of damage they cause.

The kinds of disease they spread.

Answers

Answer:

A crawling and roping

They can help us identify the insect

First, you introduce to the parents the importance of karyotype test, by describing its ability to detect two broad categories of abnormalities in chromosomes, (1)______________________ and (2)_______________________. You provide a few examples of genetic disorders that can be caused by chromosomal abnormalities, such as (3)_________________________ and (4)_____________________. Some parents would like to know what is the main cause of these genetic disorders. Without going into too much detail, you explain to them that chromosomal abnormalities are usually caused by (5) ____________________ in meiosis I and meiosis II, when the homologous chromosomes or sister chromatids fail to separate during meiotic cell division.

Answers

Answer:

Abnormalities in Chromosomes

1. Numerical

2. Structural

3. Down Syndrome

4. Turner Syndrome

5. Disorder or Error

Explanation:

Numerical chromosome abnormalities occur due to extra or missing chromosomes.  Structural chromosome abnormalities occur due to the irregular formation or rearrangement of the chromosomal DNA, normally called translocation.  Down syndrome occurs with extra chromosomes, more than 46. Turnover syndrome results from partial or missing X chromosomes, less than 46.

animals with scales on skin are called?



Answers

Answer:

Animals with scales on their skin are called reptiles..

hope it helps

stay safe healthy and happy...

When an organism encounters nitrate in its environment, which condition will determine whether the nitrate is used in an assimilatory or dissimilatory manner?

a. low concentration or ammonia
b. low concentration of sulfate
c. oxygen present
d. low temperature
e. oxygen absent
f. high concentration of nitrite

Answers

Answer:

Dissimilatory- oxygen absent

Assimilatory- high concentration of nitrite

Explanation:

In assimilatory nitrate reduction, ammonium is produced and subsequently incorporated into biomass to build up e.g., proteins and nucleic acids. Dissimilatory nitrate reduction is a process for energy conservation, in which nitrate is used as an electron acceptor in the (near) absence of oxygen . Dissimilatory nitrate reduction and nitrate storage in particular are physiological life traits that provide microbes with environmental flexibility (i.e., metabolic activity under both oxic and anoxic conditions) and resource independence (i.e., anaerobic metabolism without immediate nitrate supply), respectively. Such life traits are especially important in environments that are temporarily anoxic and/or nitrate-free and they may have developed as a “life strategy” in both prokaryotes and eukaryotes

Answer this question properly​

Answers

that looks like a penis

A solid reactant is placed into a beaker of a warm water. The liquid vigorously bubbles as the solid dissolves into the solution. What will most likely happen if the temperature of the liquid is slightly reduced?
More bubbles will be produced because the solution is becoming more concentrated.
Fewer bubbles will be produced because of fewer collisions of reactant molecules.
The solid will get smaller at a faster rate because of more collisions of reactant molecules.
The solid will get larger at a slower rate because precipitate is coming out of the solution.

Answers

Answer: Fewer bubbles will be produced because of fewer collisions of reactant molecules.

Answer:

B) Fewer bubbles will be produced because of fewer collisions of reactant molecules.

Explanation:

on Edge


130 and 14C are isotopes of 12C, which has 6 electrons, 6 protons, and 6 neutrons. What is the arrangement of subatomic particles in 14c?
A. 6 electrons, 7 protons, and 6 neutrons.

Answers

The correct answer is C. 6 electrons, 6 protons, and 8 neutrons.

Explanation

An isotope is a type of atom that is characterized by having a nucleus with a different number of neutrons. Additionally, isotope atoms are those that have the same number of protons in the nucleus (in the case of carbon 6 protons), but different mass numbers. In the case of the isotope of carbon, it has 8 neutrons (2 more neutrons than the regular carbon) and 6 protons in the nucleus, that is, that its mass is 14 (6 protons + 8 neutrons equals 14). According to the above, the correct answer is C.

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7.You invested in long-term corporate bonds and earned 6.1 percent. During that same time period, large-company stocks returned 12.6 percent, long-term government bonds returned 5.7 percent, U.S. Treasury bills returned 4.2 percent, and inflation averaged 3.8 percent. What average risk premium did you earn The durations (minutes) of 26 electric power outages in Shah Alam over the past five years are shown below. 32 44 25 66 27 12 62 9 51 4 17 50 35 99 30 21 12 53 25 2 18 24 84 30 17 17 (a) Find the mean, median and mode. Object A has a mass of 12kg. Object B has a mass of 11.5kg. Which object has more inertia? Explain your answer in the box below Which value of X makes the quotient of (5x^5+90x^2-135x)/(x+3) undefined A -2B -3C -4D -1 WILL GIVE BRAINLIST!Directions: Answer each of the questions below. Answer each question in paragraph form using complete sentences, proper capitalization, and punctuation.A. Evaluate the presidency of Andrew Jackson. 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There should have been the Last Rites and a funeral Mass at the very least."Based on this excerpt, what can be inferred about Father Pauls feelings?He secretly feels frustrated that Leon and the Pueblo people hold on to their traditional beliefs.He hopes to convince the Pueblo people to convert from their traditional beliefs to Christianity.He is upset because he is unable to stand up to Leons demands and manipulations.He is discouraged because Leon does not view the holy water as a holy symbol. A pilot drops a bomb from a plane flying horizontally. Where will the plane be located when the bomb hits the ground URGENT 50 POINTSWhich equation does the graph below represent? find missing side of triangle, help! There are 200 blue balls and 10 red balls in an urn. 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The standard error of your estimate of the average height in the city is When two aqueous solutions that differ in solute concentration are placed on either side of a semipermeable membrane and osmosis is allowed to take place, the water will Group of answer choices exhibit a net movement to the side with lower solute concentration. exhibit a net movement to the side with lower free water concentration. exhibit an equal movement in both directions across the membrane. exhibit a net movement to the side with higher free water concentration What must be the reaction force when someone hits a tree with an axe? Express 600g as a ratio of 1kgplease show working. Find the most general antiderivative of the function. (Check your answer by differentiation. Use C for the constant of the antiderivative.)g(t) = 4 + t + t2tG(t) = Part 1 a) Well done! From 2007 Q4 to 2009 Q2, real GDP fell from $15,762 to $15,134.1, or by -3.58%.b) That's right! The deflator rose from 93.15 to 94.84, or 182%. If you put 1.74%, that's an approximation. Part 2. Good! In each of those quarters, real GDP was lower than in the previous quarter. Part 3. You had the right idea, but you assumed that real GDP grow at 3% for only one yearBy the end of 2009, the economy had recovered slightly; however, the economy was still smaller than it was two years prior. From 2007 to 2009, real GDP had fallen from $15,762 billion to $15,356 billion. How deep was the recession?Suppose that the long-run growth trend of real GDP was 3% per year. If the economy had grown at 3% per year since 2007, there was a shortfall of_____billion at the end of 2009. The weight of a body is 600 N. 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