A study is done on a group of families in Sweden that are segregating a genetic disorder. A statistical estimate of whether two genes, or a gene and a disease gene, are likely to be located near each other on a chromosome (called Lod-score analysis) indicates that the gene involved in the disorder shows a strong likelihood of linkage with a particular DNA marker locus. However, a second study done in Italy with other families segregating the same genetic disorder results in lod-score values that strongly indicate the lack of linkage between the gene and the same DNA marker locus. Assuming that both studies were performed appropriately, what is the most likely explanation for the different outcomes

Answers

Answer 1

Answer:

This disorder is caused by mutations in either of two different genes; one of these genes is linked to the DNA marker locus and the other gene is not.

Explanation:

A gene marker (also known as a molecular marker) is defined as a particular DNA sequence that has a specific physical location on a given chromosome. The gene markers are always physically linked with genes of interest, thereby they are useful for identifying patients affected by a given disease and/or a particular phenotypic trait. In this case, in the first study, genetic variation of the marker has been shown to be useful to map one locus that is associated with the disease phenotype. However, in the second study, a second locus that is not linked to the marker can segregate independently, thereby showing different results from the first study (in this case, it is imperative to develop a new genetic linkage analysis to discover genetic markers linked to the second gene, which is also responsible for the disease phenotype).


Related Questions

2) ¿Cuál de los siguientes hechos no es una evidencia de una reacción química? a) Presencia de un catalizador b) Cambio de color d) Liberación de gas​

Answers

Answer:

a) Presencia de un catalizador

Explanation:

Los dos tipos de cambios que experimentan las sustancias en la química son cambios químicos y físicos.

Un cambio físico es un cambio es un cambio en el que la sustancia cambia en su apariencia o su forma de una manera que es reversible y en la que no se forma una nueva sustancia.

Un cambio químico es aquel en el que hay un cambio en las sustancias presentes y se forma una nueva sustancia.

La evidencia de que ha tenido lugar un cambio químico incluye

1) La formación de un precipitado a partir de la mezcla de sustancias.

2) Un cambio en el color de las sustancias.

3) Un cambio en el olfato (que desprende un olor) o en el sabor.

4) La sustancia produce luz (brilla)

5) El volumen total cambia

6) Cambio de temperatura (la mezcla se calienta o enfría)

Por lo tanto, la presencia de un catalizador, que es una sustancia que no participa en una reacción pero aumenta la velocidad de reacción, no es evidencia de una reacción química.

Soil is a mixture of eroded rock and: ii. rhizopus biotic iii. humus i. aquous iv. cycas v. rhizopus​

Answers

Answer:

organic Matter is the mixture of soil

urgent please answer ​

Answers

Protozoa Bacteria is the answer.

Which is a molecule found in the body?
O urethra
O nutrients
O atoms
O water

Answers

Answer:

water

Explanation:

Answer:

Water

Explanation:

Which ocean borders the western coast of South America

Answers

Answer:

Pacific Ocean

Explanation:

here is your answer

The Pacific Ocean borders the western coast of south america

An object moves 100m in 5sec, Calcutta speed.
pls answer my question!​

Answers

from g00gle!
if it doesnt let you see its 44.74 mph

what are hereditary materials​

Answers

Answer:

DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person's body has the same DNA.

Answer:

DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person's body has the same DNA.19-Jan-2021

A scientist makes a discovery that suggests a hominid species created and used relatively sophisticated tools. The scientist decided to publish his findings. Which of the following sources would be regarded as the most reliable?

Answers

a journal reviewed by peers

Answer: The answer is A Journal Reviewed By Peers

Explanation:

What describes how individuals are distributed, or spread, throughout their habitat.

1: Population density
2: Population distribution

Answers

Population Distribution, mark brainliest if this helped!

Economic impact of agricultural pollutants on water sustainability for agricultural production. summarise your findings in a table form​

Answers

Answer:

nalaqdua

Explanation:

sbospka ai9wlhzux5 s8fvekg

Question 10 of 34
Which of the following best describes the function of the human nervous
system?
A. The nervous system transports oxygen and nutrients to the body's
tissues,
B. The nervous system collects and responds to information about
the internal and external environment,
C. The nervous system protects internal organs and assists with
movement.
D. The nervous system protects the body against infection and helps
regulate body temperature,

Answers

Answer:

B. The nervous system collects and responds to information about

the internal and external environment,

Explanation:

The nervous system is the major controlling, regulatory, and communicating system in the body. It is the center of all mental activity including thought, learning, and memory. Together with the endocrine system, the nervous system is responsible for regulating and maintaining homeostasis.

The answer is B . Nervous system collects and responds to information about the internal and external environment as mervous system controls the regulatory mechanism of the body.

How does climate change make weather more extreme?

Answers

Answer:

Organized severe weather occurs from the same conditions that generate ordinary thunderstorms: atmospheric moisture, lift (often from thermals), and instability. A wide variety of conditions cause severe weather. Several factors can convert thunderstorms into severe weather.

Explanation:

I hope it will help you

A newborn that is SGA would be at risk for which of the following complications?

I. Diabetes
II. Obesity
III. Shoulder Dystocia
IV. Heart Disease

Answers

A newborn that is SGA would be at risk for suffering from Diabetes or Hypoglycemia (Option I).

What is diabetes?

Diabetes is a disease where the individual cannot control the levels of glucose in the blood.

A newborn that is Small for Gestational Age (SGA) shows an increased risk of suffering from Hypoglycemia due to the lack of control of glucose in blood.

In conclusion, A newborn that is SGA would be at risk for suffering Hypoglycemia (Option I).

Learn more about Small for Gestational Age here:

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Forces that act in pairs are said to be _____________.

A. Stable
B. Unbalanced
C. Unstable
D. Balanced

Answers

The answer is A, stable.

Which of the following is present in eukaryotes......
A) Cell wall B) Flagellum
C)Diploid nucleus D) membrane bounded organelles

Answers

D. membrane bounded organelles

Answer:

Membrane bounded organelles are present in eukaryotes..

Explanation:

hope it is helpful to

Una especie de mariposa presenta rasgos fenotípicos diferentes entre los miembros de sus poblaciones. Estos rasgos van desde una coloración verdosa y antenas cortas (características recesivas). El fenotipo más común (características dominantes) de esta especie es de coloración amarilla y de antenas tan largas que se pueden doblar. Realice el cruce entre dos mariposas que presentan fenotipo más común, pero de genotipos heterocigotos y determine los posibles rasgos fenotípicos que se pueden presentar.

Answers

Answer:

can you please translate for us into English

Which best illustrates the result of the process of meiosis?
A pea plant has the same flower color as its parent plants.
A daughter looks different from both her mother and her father.
A cheetah cub has very similar fur to its mother.
A Labrador puppy looks exactly like its father.

Answers

Answer:

B. A daughter looks different from both her mother and her father.

Explanation:

A daughter looking different from both her mother and father illustrates the process of meiosis because the cells produced are non-identical to the original cells.  

Answer:

B) A daughter looks different from both her mother and her father.

Explanation:

100% on Edge

How Can I Explain Why A Theory Is Also A Hypothesis?

Answers

Answer:

well a hypothesis is literally a scientific assumption or theory used to describe what they think is going to happen during a experiment

Binary Fission and Mitosis are similar processes. One way they are different is that: A. In Binary Fission, the DNA does not form into chromosomes. B. They both split by growing a new cell wall. C. In Mitosis, the DNA does not form into chromosomes. O D. Binary Fission only occurs in Eukaryotes.

Answers

Answer:

C. In Mitosis, the DNA does not form into chromosomes

How do simple organisms exchange substances?

Answers

Answer:

A simple, unicellular organism (consisting of one cell) can rely on diffusion to move substances into and out of the cell. Its surface area is large compared to its volume , so nutrients and other substances can pass quickly through the membrane and around its 'body'.

How do animals and people cause weathering?

How do plants cause weathering ?

Answers

Answer:

Plants can cause mechanical and chemical weathering

Explanation:

Plants can cause mechanical and chemical weathering. When plants cause mechanical weathering, their roots grow into rocks and crack them.It can also happen in streets or sidewalks. When plants cause chemical weathering, there roots release acid or other chemicals, onto rocks, which then forms cracks, and breaks apart.

Animal and plant mobility is a factor in biological weathering, for instance, a plant may grow in a gap in a rock and, as its roots spread, cause the fracture to expand.

What is the cause of weathering?

A rabbit may also burrow into a crack in a rock, making it wider and eventually separating the rock.

Animals and plants can act as mechanical weathering agents. In dirt that has gathered in fractured rock, a tree seed may emerge. The fissures get wider as the roots spread out, finally shattering the rock into pieces.

Even big rocks might get dislodged by trees over time, rocks are broken down by plants like moss that absorb their minerals.

Therefore, holding onto soil and rocks is another way that plant roots cause weathering, and might stop erosion.

Learn more about weathering, here:

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Does cellular respiration follow the law of conservation of energy?

Answers

Yes. Every chemical reaction obeys the law of conservation of mass.

Believe it!!

Pls follow me.

The Paleo-Indian skull of Kennewick Man, dated to 8,400 years B.P. is long and narrow; the face and jaws are robust, is an anatomical difference with late prehistoric and living Native Americans that have short, round skulls with gracile faces. In what state of the USA was Kennewick Man located

Answers

Answer:

Washington, near Seattle

Explanation:

Found in 1996 in Columbia park at the bottom of the Columbia River

This is land currently owned by the US Army Corps of Engineers

¿Cuál es la importancia de la colonización de habitad para la ecología?

Answers

Answer:

i dont speak spanish so ya but thanks for the points

Explanation:

Plant roots are more easily able to absorb ammonium that has been produced from ________.

A. nitrification
B. nitrogen fixation

Answers

Plants roots are more easily able to absorb ammonium that has been produced from nitrogen fixation

Mateo and Tomás are identical twins. Mateo was raised by his father and mother, and Tomás was
accidentally placed with another family after a mix-up at the hospital. At the age of 15, the boys ran into
each other at a football game and noticed that they appeared to be mirror images of each other. After
genetic testing proved that they are twins, the families discussed some of the differences between the boys.
Mateo is very athletic and intelligent and excels in basketball, but he does not take school seriously and has
F's in all subjects. Tomás is also athletic and intelligent and excels in baseball, and he makes straight A's as
a result of his strict home life and study routine. Although they are identical twins, what do you think
accounts for the differences in the two boys' academic performance based on the research?

Answers

Answer:

boboboboobbb

Explanation:

step by step

Need help write some for me to put in my book

Answers

Answer:

Users encounter the error message ‘The Third-party INF doesn’t contain Digital Signature Information’ when they are trying to install third-party drivers on their computer. There are usually two types of drivers present i.e. third-party (these are not developed by manufacturers) and official drivers

A zombie apocalypse wipes out almost the entire human species before the zombie threat is eliminated. It appears that only a group of 100 people who were at a family reunion on an uninhabited island survived. They returned to the mainland completely unaware of what had happened to everyone. Answer the following questions regarding the few survivors that now begin to rebuild the human population.

Certain traits will have been lost from the gene pool forever. Some may be obvious, like people with red hair and double jointed thumbs. Others will be less obvious, like the ability to process cholesterol or being allergic to peanuts.

a.) Which of the following best describes the mechanism of microevolution that has altered the human gene pool? Explain.

b.) Despite an abundance of habitat, why will it be difficult for the human species to recover in numbers?

c.) A straggler with green eyes stumbles into the last remaining human outpost. The green eye trait did not exist in the outpost before her arrival, but it does now. What is the name of this mechanism of evolution? Explain.

Answers

Answer and Explanation:

A. Hello. You did not enter answer options. However, we can state that mutation, natural selection and genetic drift will be the microevolution mechanisms that will affect the gene pool of these humans. This is because the new environment and the small number of living beings, will make this population completely susceptible to all these evolutionary factors, which will affect, in different ways, the gene frequencies in a population.

B. As the amount of living beings and human beings has become very small, the world will have a low genetic diversity. This will make it difficult for these humans to adapt to the new environment and will make them more susceptible to possible diseases that will arise in this new environment. This will make these humans more fragile and make it harder for them to multiply.

C. The evolution mechanism is the Gene Flow. Gene Flow refers to the exchange of genetic information between individuals in a population, through the donation of gametes that occur in reproductive processes. In this case, we can consider that the individual with green eyes, upon arriving in the community with individuals without green eyes, began to reproduce descendants, who, upon receiving the gametes responsible for green eyes, began to populate this community with this characteristic.

What is the process that human
beings undergo to release ATP from
carbohydrates?
A. cell duplication
B. cellular genesis
C. cellular respiration
D. photosynthesis

Answers

Answer:

[tex]\huge\boxed{\sf Option \ C}[/tex]

Explanation:

Cellular respiration is the process in which carbohydrates (Glucose) are broken down into carbon dioxide and water in the presence of oxygen and a lot of energy is released which is further used for ATP synthesis and ATP is released!

[tex]\rule[225]{225}{2}[/tex]

Hope this helped!

~AH1807Peace!

Which prediction is true based on this population pyramid?

The population is not growing.


The population is growing slowly.


The population is growing rapidly.


The population is declining.

Answers

I would say the population is growing slowly.

Hopefully that’s right.
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Diaz conducts a decision-making experiment to determine if people reason more logically when they have more time to decide. All the participants who are under 40 are allowed 15 minutes to reach a decision about a problem; all the participants who are over 40 are allowed 20 minutes to reach a decision about the same problem. Diaz has a problem with his experimental design because Investing $2,000,000 in TQM's Channel Support Systems initiative will at a minimum increase demand for your products 3.0% in this and in all future rounds. Looking at the Round 0 Inquirer for Andrews, last year's sales were $163,189,230. Assuming similar sales next year, the 3.0% increase in demand will provide $4,895,677 of additional revenue. With the overall contribution margin of 34.1%, after direct costs this revenue will add $1,669,426 to the bottom line. For simplicity, assume that the demand increase and margins will remain at last year's levels. How long will it take to achieve payback on the initial $2,000,000 TQM investment, rounded to the nearest Which type of market is the least likely to have an official currency? How to solve (2.31*10^-6)+(3.41*10^3) List four occasions on which Peter spoke with grace and boldness in the book of Acts. Which of the following events best illustrates how the rule of law can protect the common good?A. An official sells his car and gives the profits to charity.B. An official buys her own fuel for her government vehicle.C. Officials approve a construction project that will create more homes.D. Officials pass a law that new construction must not pollute nearby water. whats i have not meet your parents but in passive voice name of seven province on nepal By 1932, a. President Hoover was sullen and withdrawn. b. All of the above. c. The army had dispersed the Bonus Marchers, veterans of World War I, using tanks and mounted cavalry. d. Unemployment in the United States was almost 24 percent. Why did Britain oppose the idea of self-determination in the Fourteen Points plan? I'm not sure how to do this.. Help a bro out..? if (a+10) and (a+20)are supplementary angles,find them What is the most expensive mandatory spending program for the federal government? A. Medicare B. education C. Social Security D. public transportation Read the selection and the question, and choose the option that best answers the question.Hello! My name is Marina and I live in Colombia. I am 15 years old and I am in high school. In Colombia, the high school has four different routes:Technical programs (12 years)Technology programs (3 years)Teaching programs (45 years)Professional programs (45 years)I study in the technical program. I love animals and I like healthy food like fruits and vegetables. When you finish the two years of the technical program, you can start working immediately. My friend Sal has been studying a career in the technical program for two years as well. He studies how to measure streets and avenues when they want to build or put up new roads. You can start working in a month.In professional careers, you need to study more than in technical careers. My cousin Anastasia studies computers in the technology course. She loves technology.What career is Marina going to school for? Farmer Surveyor Accountant Engineer After an accident, David has trouble moving his left arm and feeling things with his left fingers. The doctor tells him this is due to brain damage in his cerebral cortex. in which hemisphere is davids brain damage likely to be 3. Which of the following is NOT a part of the female reproductive system: a. uterus b. oviduct C testes d. all of the above Hi,Valency of chlorine is 1. Why?Thank you Cmo se llama el proceso de sealizacin en el que las seales se secretan hacia el torrente sanguneo y se distribuyen por todo el cuerpo? Seleccione una: a.Neuronal b.Autocrina c.Endocrina d.Paracrina What needs a a living cell to survive?O Communicable diseaseO VirusO Non-communicable diseaseO Bacteria Which is NOT part of our solar system? A. The Sun B. The Milky Way C. Jupiter D. Asteroids and comets